Evidence map›Paper›PMID 41078089›Full record

ArticleAging cell2025

Preservation of Autophagy May Be a Mechanism Behind Healthy Aging.

Arsun Bektas, Shepherd H Schurman, Julián Candia, Olaya Santiago-Fernández, Susmita Kaushik, Ana Maria Cuervo, Luigi Ferrucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Links Between Autophagy and Healthy Aging.Journal of molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arsun BektasTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0009-0000-5557-7526
Shepherd H SchurmanClinical Research Core, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0000-0002-9133-7906
Julián CandiaTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0000-0001-5793-8989
Olaya Santiago-FernándezDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-5933-3104
Susmita KaushikDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-6096-5387
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-0771-700X
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0000-0002-6273-1613

Funding

NIA NIH HHS
6 · The paper itself

Abstract

Autophagy is intricately linked with protective cellular processes, including mitochondrial function, proteostasis, and cellular senescence. Animal studies have indicated that autophagy becomes dysfunctional with aging and may contribute to T cell immunosenescence. In humans, it remains unclear whether autophagy is impaired in CD4

Indexed as

AgingAutophagyCD4-Positive T-LymphocytesHealthy AgingAdultAgedAged, 80 and overAutophagosomesFemaleHumansMaleMicrotubule-Associated ProteinsYoung AdultMicrotubule-Associated ProteinsautophagyCD4+ T cellshealthy aging

Identifiers

PMID41078089
PMCPMC12611306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.