Evidence map›Paper›PMID 41078039›Full record

ArticleActa cytologica2026

Hyperthyroidism-Related Epithelial Hyperplasia as a Potential Pitfall of Thyroid Cytology: Institutional Cytomorphological Analysis of Histologically Verified Cases.

Eliisa Eveliina Viljanen, Lotta Virtanen, David Kalfert, Marie Ludvíková, Ivana Kholová

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Article in Acta cytologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Eliisa Eveliina ViljanenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Lotta VirtanenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
David KalfertDepartment of Otorhinolaryngology and Head and Neck Surgery, University Hospital Motol, First Faculty of Medicine, Charles University, Prague, Czechia.
Marie LudvíkováDepartment of Biology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Ivana KholováFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland, ivana.kholova@tuni.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyperthyroidism-related epithelial hyperplasia is seldomly listed as a pitfall in thyroid cytology. Therefore, we focused on the cytomorphological characteristics of epithelial hyperplasia and compared these features with papillary thyroid carcinoma (PTC).

methodsStudy group consisted of 76 patients (133 FNA specimens) histologically diagnosed with hyperthyroidism-related epithelial hyperplasia without a concomitant malignancy. The control group contained 21 histologically verified FNAs of PTCs. A total of 48 cytomorphological features were quantitatively evaluated.

resultsStatistically significant differences between the study groups were discovered on the architectural, cellular, and nuclear levels. Nuclear features varied most: nuclear elongation, grooves, irregular nuclear membrane, pseudoinclusions, the presence of nucleoli or small eccentric nucleoli were clearly more common in PTC group.

conclusionFine-needle aspiration referrals with clinical data and thyroid function test results can facilitate the interpretation of cytomorphological features and reduce the use of undetermined categories in cases of hyperthyroidism-related epithelial hyperplasia.

Indexed as

HyperthyroidismThyroid GlandThyroid NeoplasmsAdultAgedBiopsy, Fine-NeedleCarcinoma, PapillaryFemaleHumansHyperplasiaMaleMiddle AgedThyroid Cancer, PapillaryYoung AdultFine-needle aspirationHyperthyroidism-related epithelial hyperplasiaThe Bethesda System for Reporting Thyroid Gland CytopathologyThyroid gland

Identifiers

PMID41078039
PMCPMC13046299

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