Evidence map›Paper›PMID 41077974›Full record

ArticleNeurospine2025

Efficacy of Proximal Junctional Tethering in Spinal Fusion Surgery for Preventing Proximal Junctional Kyphosis and Proximal Junctional Failure: A Meta-analysis.

Yu-Chi Hsu, Hsuan-Tung Lee, Ying-Fong Su, Yang-Ching Chen, Serena S Hu, Ching-Chi Hsu, Pei-I Tsai, Wei-Bin Hsu, Den-Tai Lin, Ching-Yu Lee and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurospine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yu-Chi HsuSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Hsuan-Tung LeeSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ying-Fong SuDepartment of Orthopedic Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Yang-Ching ChenDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Serena S HuDepartment of Orthopedic Surgery, Stanford University School of Medicine, Redwood City, CA, USA.
Ching-Chi HsuDepartment of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Pei-I TsaiBiomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan.
Wei-Bin HsuDepartment of Orthopedic Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Den-Tai LinBiomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan.
Ching-Yu LeeDepartment of Orthopedic Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Tsung-Jen HuangDepartment of Orthopedic Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Tan Lam Minh NguyenThe International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Meng-Huang WuDepartment of Orthopedic Surgery, Taipei Medical University Hospital, Taipei, Taiwan.

Funding

Industrial Technology Research InstituteIndustrial Technology Research Institute Q356EK3100Next Generation Medical Device Key Technology Development and Application PlanTaipei Medical University Hospital Q3101
6 · The paper itself

Abstract

objectiveSpinal fusion surgery is effective for treating various adult spinal deformities. However, spinal fusion surgery is associated with the risk of adjacent segment disease (ASD; 5%-30%), particularly proximal junctional kyphosis (PJK) and proximal junctional failure (PJF). Proximal junctional tethering (PJT) has become a popular technique owing to increasing evidence that it can decrease the rate of PJK or PJF.

methodsA literature search was conducted using PubMed, Embase, and Cochrane Library. Twelve eligible studies were identified. These studies were predominantly retrospective in nature and compared the incidence of PJK or PJF in adults undergoing spinal fusion surgery with or without PJT. Risk of bias was assessed using the Newcastle-Ottawa scale. All outcomes were analyzed using R software (ver. 4.4.1).

resultsWe included 8 retrospective cohort studies and 3 propensity-score-matched analyses; these studies comprised 1,424 patients. PJT was associated with a significant decrease in the odds of development of PJK (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.27-0.71) and PJF (OR, 0.36; 95% CI, 0.19-0.69) compared with control. Subgroup analysis results revealed no significant difference in ASD rates between geographical locations, between tethering with and without crosslinks, and between specific tethering techniques.

conclusionPJT significantly reduces the odds of both PJK and PJF in adults undergoing spinal fusion surgery.

Indexed as

Adjacent segment diseaseAdult spinal deformityProximal junctional failureProximal junctional kyphosisProximal junctional tetheringSpinal fusion surgery

Identifiers

PMID41077974
PMCPMC12518914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.