Evidence map›Paper›PMID 41077795›Full record

ArticleInternational neurourology journal2025

Altered Periaqueductal Gray Functional Connectivity in Overactive Bladder Patients: A Resting-State Functional Magnetic Resonance Imaging Study Using Clustering Analysis.

Susana Fernández Chadily, Naomi R van Houtum, Marianne E van Klaveren, Armelle Knops, Gommert A van Koeveringe, Mathijs M de Rijk, Job van den Hurk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International neurourology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susana Fernández ChadilyDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Naomi R van HoutumDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Marianne E van KlaverenDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Armelle KnopsDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Gommert A van KoeveringeDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Mathijs M de RijkDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Job van den HurkDepartment of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Funding

Faculty of Health, Medicine and Life Sciences of Maastricht UniversityNederlandse Organisatie voor Wetenschappelijk Onderzoek 18954
6 · The paper itself

Abstract

purposeOveractive bladder (OAB) syndrome is a subset of storage lower urinary tract symptoms that significantly affects health-related quality of life, impacting social, occupational, and psychological well-being. Although the precise pathophysiology of OAB remains unclear, disruption of the neural network that regulates lower urinary tract activity has been suggested. The brain-bladder axis depends on a complex and extensive network of brain regions, with the periaqueductal gray (PAG) playing a pivotal role in mediating bidirectional communication.

methodsThis study investigates whether the functional connectivity-based organization of the PAG in human subjects changes dynamically over time. OAB patients and healthy controls (HC) underwent resting-state functional magnetic resonance imaging at 7 T, beginning with an empty bladder (subsensory threshold bladder filling state). Functional connectivity-based clustering analysis was performed to evaluate time-dependent changes in PAG organization.

resultsSignificant group differences in time-dependent PAG functional organization were observed (P=0.017). In HC, functional subdivisions of the PAG reorganized dynamically during the resting-state scan, whereas OAB patients displayed a largely static functional organization, showing minimal change over time.

conclusionThese findings indicate altered PAG signaling and differences in sensory processing among OAB patients. The absence of dynamic PAG reorganization may contribute to OAB pathophysiology, offering new insight into its neural mechanisms.

Indexed as

Brain mappingFunctional magnetic resonance imagingOveractive bladderPeriaqueductal gray

Identifiers

PMID41077795
PMCPMC12516135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.