Evidence map›Paper›PMID 41077767›Full record

ArticleCardiovascular research2025

Tirzepatide protects the heart from doxorubicin-induced cardiotoxicity by modulating endoplasmic reticulum (ER) stress and HMGCoA reductase 1 expression.

Christopher C Glembotski

Abstract readEditorialComment
In one paragraph

Article in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Christopher C GlembotskiTranslational Cardiovascular Research Center, University of Arizona College of Medicine-Phoenix, 435 N. 7th Street, Phoenix 85004, AZ, USA.ORCID 0000-0002-1380-5073

Funding

Non-canonical ERAD as a Regulator of Cardiac HypertrophyR01HL157027 · NHLBI · UNIVERSITY OF ARIZONA · PI GLEMBOTSKI, CHRIS · 2022 to 2025
$2.6M
Roles for endoplasmic reticulum associated degradation (ERAD) in Myocardial ProteostasisR01HL174576 · NHLBI · UNIVERSITY OF ARIZONA · PI Chris Glembotski · 2024 to 2026
$2.1M
NHLBI NIH HHS R01 HL157027NHLBI NIH HHS R01 HL174576NIH HHS HL157027NIH HHS HL174576
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41077767
PMCPMC12551385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.