Evidence map›Paper›PMID 41077708›Full record

ArticleThe Journal of infectious diseases2026

Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma.

Ilona Argirion, Aisha Babi, Julia Simon, Tim Waterboer, Wan-Lun Hsu, Chien-Jen Chen, Kelly J Yu, Miranda Pring, Katrina Hurley, Allan Hildesheim and 1 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilona ArgirionDepartment of Human Science, School of Health, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-4925-5296
Aisha BabiDivision of Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-2726-6955
Julia SimonDivision of Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Tim WaterboerDivision of Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-0616-6963
Wan-Lun HsuData Science Center.
Chien-Jen ChenGenomics Research Center, Academica Sinica, Taipei, Taiwan.ORCID 0000-0002-6996-9069
Kelly J YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0003-3832-6586
Miranda PringBristol Dental School, University of Bristol.ORCID 0000-0003-4658-5772
Katrina HurleyNational Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom.
Allan HildesheimDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0003-0257-2363
Zhiwei LiuDepartment of Human Science, School of Health, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-0136-651X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV) causes most nasopharyngeal carcinoma (NPC), a malignancy endemic in certain regions, presenting with nonspecific symptoms and lacking a robust minimally invasive biomarker. To assess previously developed multiplex Luminex assay EBV antibody signatures in a nonendemic population, we analyzed and compared 98 NPC sera and 142 matched controls from the nonendemic Head and Neck 5000 clinical cohort against an endemic Taiwan case-control cohort. All models, except the 2-antibody IgA panel, performed similarly, achieving 90%-99% accuracy in identifying EBV-positive NPC. Our results showed that EBV antibody panels can accurately define EBV-positive NPC regardless of endemicity.

Indexed as

Antibodies, ViralEpstein-Barr Virus InfectionsHerpesvirus 4, HumanNasopharyngeal NeoplasmsAdultAgedCarcinomaCase-Control StudiesEndemic DiseasesFemaleHumansImmunoglobulin AMaleMiddle AgedNasopharyngeal CarcinomaTaiwanAntibodies, ViralImmunoglobulin AantibodiesendemicityEpstein-Barr virushumoral immune responsenasopharyngeal carcinoma

Identifiers

PMID41077708
PMCPMC13381283

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.