ArticleActa paediatrica (Oslo, Norway : 1992)2026
Low ICU Admission and Excellent Outcomes in MIS-C: A Swedish Study From an Open Society.
Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimDuring the COVID-19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS-C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock.
methodsNationwide population-based cross-sectional study. All children and adolescents from 0 to 19 years of age with MIS-C from March 2020 to August 2022 were included. Multivariable logistic regression with ICU admission and cardiogenic shock as outcomes was used to evaluate risk factors for severe disease.
resultsA total of 338 MIS-C cases were identified; 69 patients (20%) required intensive care and 38 patients (11%) developed cardiogenic shock. Clinical findings associated with ICU admission were cardiac involvement: OR 14.00 (6.28-34.70), airway involvement: OR 6.75 (3.23-14.80), hyperinflammation: OR 3.25 (1.34-7.97), oedema: OR 2.40 (1.07-5.44) and diarrhoea: OR 2.23 (1.07-4.80). Clinical findings associated with cardiogenic shock were hyperinflammation: OR 5.10 (2.16-12.00), airway involvement: OR 4.87 (2.12-12.00), higher age (13-19 vs. 0-5 years): OR 3.85 (1.17-15.60), obesity: OR 3.55 (1.14-10.5) and diarrhoea: OR 2.48 (1.09-5.92).
conclusionIn Swedish national MIS-C cohort, the rate of ICU admission was low and outcome excellent. Identifying risk factors for ICU admission and cardiogenic shock may facilitate early detection of risk patients.
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