Evidence map›Paper›PMID 41077612›Full record

ArticleMolecular psychiatry2026

Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals.

Hayley H A Thorpe, Pierre Fontanillas, John J Meredith, Mariela V Jennings, Renata B Cupertino, Shreya R Pakala, 23andMe Research Team, Sarah L Elson, Jibran Y Khokhar, Lea K Davis and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Pooled it
  2. Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hayley H A ThorpeDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Pierre Fontanillas23andMe, Inc., Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0002-8944-4454
John J MeredithDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Mariela V JenningsDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Renata B CupertinoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3452-0632
Shreya R PakalaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
23andMe Research Team
Sarah L Elson23andMe, Inc., Sunnyvale, CA, USA.
Jibran Y KhokharDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-2169-2275
Lea K DavisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0394-777X
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. sanchezroige@ucsd.edu.ORCID http://orcid.org/0000-0001-6137-5699

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI SOLBERG WOODS, LEAH CATHERINE · 2014 to 2023
$27.4M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Tobacco-Related Disease Research Program (TRDRP) T32IR5226U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DP1DA054394U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) P50DA037844
6 · The paper itself

Abstract

Cannabis is one of the most widely used drugs globally. We performed genome-wide association studies (GWASs) of lifetime (N = 131,895) and frequency (N = 73,374) of cannabis use. For lifetime cannabis use, we identified two loci, one near CADM2 (rs35827242, p = 4.63E-12) and another near GRM3 (rs12673181, p = 6.90E-09). For frequency of cannabis use, we identified one locus near CADM2 (rs4856591, p = 8.10E-09; r

Indexed as

Marijuana AbuseMarijuana UseAdultCannabisCell Adhesion MoleculesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritancePhenotypePolymorphism, Single NucleotideReceptors, Metabotropic GlutamateCADM2 protein, humanCell Adhesion MoleculesReceptors, Metabotropic Glutamate

Identifiers

PMID41077612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.