Evidence map›Paper›PMID 41077431›Full record

ReviewThe Surgical clinics of North America2025

How the Microbiome Drives Cardiovascular Disease.

Karen J Ho, Jayalekshmi Vs, Ayah Abualhuda, Bowen Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Surgical clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen J HoDepartment of Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 650, Chicago, IL 60611, USA. Electronic address: kho1@nm.org.
Jayalekshmi VsDepartment of Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 650, Chicago, IL 60611, USA.
Ayah AbualhudaDepartment of Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 650, Chicago, IL 60611, USA.
Bowen WangDepartment of Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 650, Chicago, IL 60611, USA.

Funding

Targeting the Meta-organismal Butyrate Pathway to Prevent Arterial Restenosis after Vascular SurgeryR01HL153306 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HO, KAREN J. · 2021 to 2025
$2.8M
The Role of Amino Acid Starvation Response Kinase GCN2 in Abdominal Aortic AneurysmR01HL162895 · NHLBI · UNIVERSITY OF VIRGINIA · PI Bowen Wang · 2022 to 2026
$2.0M
COCOA PAD II: Effect of Cocoa Flavanols on the Gut Microbiome and Functional PerformanceR21AG081706 · NIA · UNIVERSITY OF CHICAGO · PI HO, KAREN J., POLONSKY, TAMAR S. · 2023 to 2023
$487k
NHLBI NIH HHS R01 HL153306NHLBI NIH HHS R01 HL162895NIA NIH HHS R21 AG081706
6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are the leading causes of death and disability globally. Scientific and clinical evidence demonstrate that gut microbiota influence the development and natural history of CVDs through regulation of the immune/inflammatory response, intestinal barrier function, and metabolic pathways. This article provides an overview of the relationships between gut dysbiosis and coronary artery disease, heart failure, cardiovascular death, cerebrovascular disease, peripheral artery disease, and aortic aneurysms and how these relationships may lead to novel interventions for disease prevention and treatment.

Indexed as

Cardiovascular DiseasesDysbiosisGastrointestinal MicrobiomeHumansCardiovascular diseasesCerebrovascular diseaseCoronary artery diseaseDysbiosisGastrointestinal microbiomeHeart failureHypertensionPeripheral artery disease

Identifiers

PMID41077431
PMCPMC13579640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.