ArticleJournal of clinical periodontology2026
Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri-Implant Lesions.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- Impact of OMICS Technologies in Our Understanding of the Pathogenesis of Peri-Implantitis.Clinical and experimental dental research · 2026Review
- Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri-Implant Lesions.Journal of clinical periodontology · 2026Article
- Peri-Implant Diseases: The Past, the Present, the Future.Journal of periodontal research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimTo analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri-implantitis. MATERIALS AND
methodsSoft-tissue biopsy samples obtained from patients presenting with implants with severe peri-implantitis and adjacent reference implants with no signs of peri-implantitis were analysed by spatial transcriptomics (n = 4), RNA-sequencing (n = 20) and immunohistochemistry (n = 38).
resultsThe analysis disclosed evident associations between distinct gene clusters and specific tissue compartments in both groups of specimens. Samples from peri-implantitis sites showed higher levels of gene activity than samples from reference implant sites. Gene-set enrichment analysis revealed that several important biological pathways, for example, 'regulation of antimicrobial host response', 'collagen fibril organisation' and 'regulation of angiogenesis', were severely dysregulated in peri-implantitis lesions when compared to reference implant sites. Similarly, immunohistochemical evaluation showed elevated levels of proteins corresponding to the most up-regulated, differentially expressed genes (DEGs), which were identified by spatial transcriptomics and RNA-sequencing.
conclusionsPeri-implant lesions demonstrated associations between gene clusters and specific tissue compartments. Several biological pathways linked to the activation of host response towards bacterial insults were dysregulated in peri-implantitis specimens when compared to reference implant samples.
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