ArticleNeuroImage2025
Chronic radon exposure is associated with developmental alterations to neural and behavioral indices of cognitive control.
Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Radon-related increases in depressive symptoms are explained by amygdala morphology and external locus of control.Neurotoxicology · 2026Article
- The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth.Neurotoxicology · 2026Article
- Inflammation-related aberrations in beta and gamma oscillatory dynamics serving attention processing in typically developing youth.Brain communications · 2026Article
- Evidence of decreased neural efficiency supporting fluid reasoning abilities in children and adolescents chronically exposed to home radon.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Radon is a prevalent, naturally occurring gas which contributes to radiation within the environment and is the second-leading cause of lung cancer worldwide. Although many environmental toxins have been linked to maladaptive neurodevelopmental outcomes in children and adolescents, radon has seldom been examined for its effects on the developing brain. This study aimed to investigate the effects of chronic home radon exposure on top-down neural processes of cognitive control in youths. Fifty-nine participants (aged 6-14 years) completed a Simon interference task during magnetoencephalography (MEG), and radon levels were measured in their homes. MEG data were transformed into time-frequency space and significant oscillatory responses relative to baseline were imaged condition-wise and then subtracted to isolate the Simon interference effect (i.e., Simon-control). Whole-brain linear regressions indicated that children with greater radon exposure exhibited aberrant oscillatory activity in widespread networks related to attentional control. We also found that radon exposure moderated the developmental trajectory of theta and gamma oscillations underlying selective attention in frontoparietal cortices and other regions. Further, mediation analyses showed that the neural interference effects within cerebellar and extended motor cortices mediated the relationship between radon exposure and behavioral outcomes. Additionally, we found the mediating effects of neural interference within the left superior frontal gyrus and precuneus on the relationship between age and task accuracy were dependent on radon exposure. These data are among the first to demonstrate radon-related disruptions to the normative development of the neural substrates supporting cognitive control processes. Further, these disruptions have direct implications on observable behavior.
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