Evidence map›Paper›PMID 41076969›Full record

ArticleDrug and alcohol dependence2025

Impacts of impaired control and pharmacological criteria for lifetime alcohol use disorder on relationships between drinking and problems.

Paul J Gruenewald, Raul Caetano, Christina Mair

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paul J GruenewaldPrevention Research Center, Pacific Institute for Research and Evaluation, 2030 Addison, Ste 401, Berkeley, CA, USA. Electronic address: paul@pire.org.
Raul CaetanoPrevention Research Center, Pacific Institute for Research and Evaluation, 2030 Addison, Ste 401, Berkeley, CA, USA. Electronic address: RCaetano@pire.org.
Christina MairDepartment of Behavioral and Community Health Sciences, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA; Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA; Center for Social Dynamics and Community Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. Electronic address: cmair@pitt.edu.

Funding

Transitions and Alcohol Use in the Later Lifespan: Environmental and Individual-level InfluencesP60AA006282 · NIAAA · PACIFIC INSTITUTE FOR RES AND EVALUATION · PI MALLIE J PASCHALL · 2003 to 2026
$41.2M
NIAAA NIH HHS P60 AA006282
6 · The paper itself

Abstract

backgroundThe contribution of criteria for lifetime alcohol use disorder (AUD) to greater drinking and problems is infrequently considered in community-based studies of alcohol users. However, theoretical and empirical work indicate that relationships between drinking and problems may be quite different among drinkers reporting impaired control (ic) or pharmacological (p) criteria related to AUD (icpAUD). In this study we measured the extent to which the presence of greater number of these criteria affected dose-response relationships between drinking and problems.

methodsA survey of 2044 "regular" drinkers reporting use at least twice a month over the previous year assessed respondents' sociodemographic characteristics, impulsivity, drinking motives, sensation seeking, drinking patterns, lifetime AUD criteria (Composite International Diagnostic Interview) and the occurrence of 18 drinking problems over the previous 28 days. Heteroskedastic Tobit regression models were used to measure impacts of two measures of impaired control (impaired control over drinking, inability to stop drinking) and three pharmacological criteria (craving, tolerance, withdrawal) on dose-response relationships between drinking and problems.

resultsA dose-response effect was observed among regular drinkers with no criteria (Χ

conclusionsMeasures of impaired control and pharmacological symptom criteria related to lifetime AUD alter dose-response relationships and greatly increase 28-day drinking problems. Therefore, assessments of lifetime AUD criteria are critical to etiological assessments of alcohol problems in community-based studies.

Indexed as

Alcohol useCravingDrinking problemsImpaired controlLifetime alcohol use disorder (AUD)Pharmacological symptom criteriaToleranceWithdrawal

Identifiers

PMID41076969
PMCPMC12541909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.