Evidence map›Paper›PMID 41076635›Full record

ArticleJournal of medicinal chemistry2025

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery.

Vincent Poon, Christopher Bailey, Sandra Carvalho, Stephen Patterson, James W B Fyfe, Olga Semenova, Stephen K Wrigley, Emily Hopkins, Ravi Manohar, Christopher Drake and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Vincent PoonHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Christopher BaileyDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee Dundee DD1 5EH, U.K.ORCID 0000-0003-3335-2312
Sandra CarvalhoMode of Action Group, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Stephen PattersonMode of Action Group, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
James W B FyfeDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee Dundee DD1 5EH, U.K.ORCID 0000-0001-8501-9197
Olga SemenovaDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee Dundee DD1 5EH, U.K.
Stephen K WrigleyHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Emily HopkinsHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Ravi ManoharHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Christopher DrakeHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Tetsuo KokubunHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
John BoyleHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Lisbet KvaernoHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Kristin LeesDepartment of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion SY23 3FL, U.K.
Karl F HoffmannDepartment of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion SY23 3FL, U.K.ORCID 0000-0002-3932-5502
Josephine Forde-ThomasDepartment of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, Ceredigion SY23 3FL, U.K.
Susan WyllieMode of Action Group, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.ORCID 0000-0001-8810-5605
Jonathan SteeleHypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K.
Ian H GilbertDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee Dundee DD1 5EH, U.K.ORCID 0000-0002-5238-1314
Gary J TarverDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee Dundee DD1 5EH, U.K.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Herein, we demonstrate the use of a commercially available enzymatic kit to achieve late-stage hydroxylation of biologically relevant compounds by using the PolyCYPs screening kit. A selection of promising biotransformations were scaled up, products isolated, and structures elucidated. Isolated compounds were screened against a range of pathogens, namely,

Indexed as

Cytochrome P-450 Enzyme SystemDrug DiscoveryAnimalsBiotransformationHydroxylationLeishmania donovaniSchistosoma mansoniTrypanosoma brucei bruceiTrypanosoma cruziCytochrome P-450 Enzyme System

Identifiers

PMID41076635
PMCPMC12557363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.