Evidence map›Paper›PMID 41076614›Full record

SynthesisPlant foods for human nutrition (Dordrecht, Netherlands)2025

A Critical Review of the Health Benefits Associated with Chia Seeds (Salvia Hispanica L.).

Zena Kadhim Al-Younis, Sarmad Ghazi Al-Shawi, A K Kareem, Safia Obaidur Rab, Renuka Jyothi S, Swati Mishra, Ashish Singh Chauhan, Udaybir Singh, Ahmad Hossen, Ahmed Mohammed Ahmed

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zena Kadhim Al-YounisFood Science Department, College of Agriculture, University of Basrah, Basrah, Iraq.
Sarmad Ghazi Al-ShawiFood Science Department, College of Agriculture, University of Basrah, Basrah, Iraq. sarmad.mohammed@uobasrah.edu.iq.
A K KareemBiomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Hillah, Babil, 51001, Iraq.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Renuka Jyothi SDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Swati MishraDepartment of Pharmacology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, 751003, Odisha, India.
Ashish Singh ChauhanUttaranchal Institute of Pharmaceutical Sciences, Division of research and innovation, Uttaranchal University, Dehradun, Uttarakhand, India.
Udaybir SinghCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Ahmad HossenDepartment of medical analysis, Medical laboratory technique college, the Islamic University, Najaf, Iraq.
Ahmed Mohammed AhmedDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.

Funding

King Khalid University, Abha, Saudi Arabia R.G.P.2/517/45
6 · The paper itself

Abstract

Chia seeds (Salvia hispanica L.) have attracted interest for their potential health benefits, yet their overall effectiveness remains uncertain due to limited high-quality evidence and heterogeneity across studies. This umbrella review critically synthesizes data from systematic reviews and meta-analyses of randomized controlled trials (RCTs) to evaluate the effects of chia supplementation on key health outcomes. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science. Eligible studies assessed outcomes including blood pressure, lipid profiles, inflammation, and anthropometric measures. Methodological quality was evaluated using AMSTAR-2, and certainty of evidence was graded using GRADE. Meta-analyses were performed using Comprehensive Meta-Analysis (CMA) software v3.7, with Hedges' g and 95% confidence intervals (CI); significance was set at P < 0.05. Eight meta-analyses involving approximately 2,500 participants were included. Chia supplementation resulted in significant reductions in diastolic blood pressure (g = -0.550; 95% CI: -0.718 to -0.382), systolic blood pressure (g = -0.119; 95% CI: -0.228 to -0.010), total cholesterol (g = -0.300), LDL-C (g = -0.300), triglycerides (g = -0.200), waist circumference (g = -0.289), and C-reactive protein (g = -0.165). However, a small reduction in HDL-C was also observed (g = -0.093). Overall, chia supplementation may offer modest but statistically significant benefits for improving blood pressure, lipid profiles, inflammation, and central obesity. The certainty of evidence, based on GRADE assessments, ranged from moderate to low for most outcomes. .

Indexed as

SalviaSalvia hispanicaSeedsBlood PressureDietary SupplementsHumansInflammationLipidsRandomized Controlled Trials as TopicTriglyceridesLipidsTriglyceridesBlood pressureChiaHealth outcomesSalvia hispanica L .

Identifiers

PMID41076614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.