Observational studyDiabetologia2025
Daily life stress is linked to increased glucose levels in individuals with insulin resistance: a real-world assessment.
Observational study in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Review
- Association between perceived stress and metabolic parameters: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2026Review
- A Simple Admission-Based Score for Early Mortality Risk Stratification in Non-Shock Sepsis: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- The association between poor glycemic control and PTSD in patients with diabetes mellitus in primary healthcare in Palestine.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aims/hypothesisThe bidirectional relationship between stress and diabetes is well documented, with chronic stress increasing the risk of diabetes onset and stress adversely affecting clinical outcomes in individuals with diabetes. However, the impact of daily life stress on glucose levels in insulin-resistant individuals, who are at risk of type 2 diabetes, remains unclear.
methodsThe analysis included 116 participants (62 insulin-resistant [IR] and 54 insulin-sensitive [IS] participants) aged 18-78 years. Insulin resistance was defined by a HOMA-IR index above 2.5. Participants completed three standardised baseline questionnaires to assess their affective state. Using ambulatory assessment, daily life stress and affect were assessed for 3 days while continuous glucose monitoring was conducted for 7 days. Linear mixed-effect models were applied to estimate effects between parameters.
resultsWhile perceived daily stress was not different between individuals with insulin resistance and control participants, we found a significant positive effect of stress on blood glucose level ( CONCLUSIONS/
interpretationDaily life stress contributes to a significant increase in glucose levels in IR individuals, highlighting the need for tailored interventions to mitigate further deterioration and potential progression to type 2 diabetes. These results underscore the importance of integrating stress management strategies into diabetes prevention in at-risk populations. Ambulatory assessments can serve as monitoring tools for identifying at-risk individuals and for testing the efficacy of targeted interventions. CLINICAL
trial registrationRegistered under https://drks.de/register/de , identifier no. DRKS00022774.
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