SynthesisBritish journal of anaesthesia2025
Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression.
Synthesis in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web-Based Cross-Sectional ESAIC Survey.Paediatric anaesthesia · 2026Article
- Clinical Use of Endotracheal Intubation Without Neuromuscular Blockade: The Current Stage of Knowledge.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis is the first to compare tracheal intubation conditions and haemodynamic responses produced by various types and doses of neuromuscular blocking agents (NMBAs) in paediatric anaesthesia while also exploring factors associated with variability in outcomes.
methodsRandomised controlled and controlled clinical trials involving healthy paediatric participants (0-12 yr) were included. Trials compared intubation conditions using various NMBA interventions or NMBA-free settings under direct laryngoscopy. Outcomes included odds ratios (ORs) for excellent and acceptable intubation conditions, and mean differences for MAP and HR. Bayesian network, pairwise, and cumulative meta-analyses, along with meta-regression, assessed NMBA effectiveness and covariate effects.
resultsData from 105 trials (8008 participants) were analysed. Suxamethonium ≥1.50 mg kg
conclusionsWe present a meta-analytical approach to synthesise and consolidate evidence from previous research and demonstrate how neuromuscular blocking agent type and dose, intubation timing, age, and induction drugs affect the safety and efficacy of paediatric airway management. Low-to-moderate confidence can be assigned to the recommendations from this meta-analysis. SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD42018097146).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.