ArticleZeitschrift fur medizinische Physik2026
A low-cost, easy-to-implement optical add-on to convert a retinal OCT into a ultra-high-resolution corneal OCT.
Article in Zeitschrift fur medizinische Physik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- UV-protective sunscreen compounds and their differential accumulation across ocular tissues in fish eyes from Baltic Sea.Scientific reports · 2026Article
- Design, implementation and evaluation of non-contact in vivo confocal microscopy for capturing the human corneal endothelium from the central to near-limbal regions.Zeitschrift fur medizinische Physik · 2026Article
- Objective assessment of accommodation with an accommodative intraocular lens: Development of methodology and case report.Zeitschrift fur medizinische Physik · 2026Article
- Medical optics in medical physics: from photons to quantitative insight.Zeitschrift fur medizinische Physik · 2026Article
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6 authors.
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Abstract
purposeCommercial anterior segment optical coherence tomography (OCT) systems typically offer sufficient axial resolution to distinguish corneal layers. However, their lateral resolution (∼15-20 µm) is limited, restricting the visualization of fine microstructural features, relevant for noninvasive diagnosis of corneal pathologies. We present a low-cost, easy-to-implement optical add-on that substantially improves the lateral resolution of a standard retinal OCT system, enabling high-fidelity corneal imaging.
methodsCustom-designed optical modules were developed for the standard objective lens of an investigational retinal OCT device. The system design, incorporating a single achromatic lens, was optimized through optical simulations to achieve a higher numerical aperture and reduced focal length. The lateral resolution was evaluated both theoretically, via point spread function, and experimentally using a 1951 United States Air Force (USAF) resolution target. A compact prototype, presented here, was tested on a commercial SPECTRALIS OCT2, compared with the commercial Anterior Segment Module (both Heidelberg Engineering GmbH, Heidelberg, Germany), and tested in vivo on two human subjects, including one with suspected epithelial basement membrane dystrophy (EBMD).
resultsThe prototype achieved a lateral resolution of 3.1µm in the experiment, closely matching the results of the optical simulation. This resolution is markedly better than the 15.6µm achieved with the commercial corneal OCT, albeit at a cost of a reduced field of view (2.62mm vs. 8.29mm). In vivo imaging confirmed enhanced visualization of epithelial microstructures in both healthy and pathological corneas, despite a reduced depth of focus resulting from the higher numerical aperture.
conclusionThe proposed add-on enabled ultra-high-resolution corneal imaging on a standard SPECTRALIS OCT2 platform without the need for major hardware modifications, such as an increased reference arm or dispersion compensation. This low-cost, easy-to-implement approach offers diagnostic value for early detection and longitudinal monitoring of subtle corneal irregularities, particularly in conditions such as EBMD, where a high lateral resolution is critical for clinical decision-making.
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