Evidence map›Paper›PMID 41076158›Full record

ArticleJournal of affective disorders2026

Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.

César Higgins Tejera, Priya Duggal, Monica Diaz, Elizabeth Topper, Deborah Gustafson, Beth D Jamieson, Pauline M Maki, Anjali Sharma, Amanda B Spence, Kathleen M Weber and 7 more

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In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

César Higgins TejeraJohns Hopkins University, School of Medicine, Department of Neurology, 600 N. Wolfe Street, Baltimore, MD, 21287, United States. Electronic address: chiggi25@jh.edu.
Priya DuggalJohns Hopkins University, School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, United States.
Monica DiazUniversity of North Carolina, School of Medicine, Department of Neurology, 170 Manning Drive, Chapel Hill, NC, 27599, United States.
Elizabeth TopperJohns Hopkins University, School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, United States.
Deborah GustafsonSUNY Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, NY, 11203, United States.
Beth D JamiesonDavid Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, United States.
Pauline M MakiUniversity of Illinois Chicago, 1007 W. Harrison Street, Chicago, IL, 60607, United States.
Anjali SharmaAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, United States.
Amanda B SpenceThe George Washington University, 950 New Hampshire Avenue, Washington, DC, 20052, United States.
Kathleen M WeberRush University Medical College, 600 S. Paulina St, Chicago, IL, 60612, United States.
Andrea M WeinsteinUniversity of Pittsburg, School of Medicine, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States.
Deborah L JonesUniversity of Miami, Miller School of Medicine, Department of Psychiatry and Behavioral Science, 1600 NW 10(th) Avenue, Miami, FL, 33136, United States.
Pariya L FazeliThe University of Alabama at Birmingham, College of Arts and Sciences, Department of Psychology, 1300 University Boulevard, Birmingham, AL, 35233, United States.
Gina WingoodColumbia University, Mailman School of Public Health, 722 West 168(th) Street, New York, NY, 10032, United States.
Linda TeplinNorthwestern University, Feinberg School of Medicine, 710 N Lake Shore Drive, Chicago, IL, 60611, United States.
Leah H RubinJohns Hopkins University, School of Medicine, Department of Neurology, 600 N. Wolfe Street, Baltimore, MD, 21287, United States.
Kathryn C FitzgeraldJohns Hopkins University, School of Medicine, Department of Neurology, 600 N. Wolfe Street, Baltimore, MD, 21287, United States.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIA NIH HHS K23 AG076663NIMH NIH HHS K23 MH131466NIMH NIH HHS P30 MH075673NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

backgroundWomen with HIV (WWH) experience high depression rates and cognitive impairment. Biological models suggest that depression is a scar on the brain, but large longitudinal studies on its specific cognitive effects are scarce. WWH may be more susceptible to these effects than women without WIH (WWoH). We estimated the association between depressive symptoms and domain-specific cognitive impairment in the Women's Interagency HIV Study.

methodsParticipants were followed until cognitive impairment onset. Depression burden was calculated using Center for Epidemiologic Studies Depression scale (CES-D) scores. We interpolated CES-D scores into proportion values and used them with the time elapsed between visits to calculate the percent of days with depression (PDD). Domain-specific cognitive impairment was defined as 1-SD below mean performance in each domain attention/working memory, verbal memory, verbal learning, executive function, processing speed, verbal fluency, and motor function. Marginal structural Poisson models were used to estimate incidence rate ratios (IRRs) of cognitive impairment.

resultsAmong 2536 participants (1757 WWH; mean age = 45.7 y; 71 % non-Hispanic Black; 18 % Hispanic), the average PDD over 12.8 years was 23.4 %. Overall, a 1-SD above mean PDD (i.e., 23-48 % increase) was associated with higher risk of impairment in attention/working memory (IRR = 1.24; 95 %CI: 1.08, 1.44), executive function (IRR = 1.43; 95 %CI: 1.18, 1.72) and verbal learning (IRR = 1.20; 95 %CI: 1.05, 1.37). HIV serostatus did not modify these associations.

conclusionsLow-income women of color spend 23 % of their lives with depressive symptoms, a burden contributing to cognitive impairment. Addressing mental health is crucial for optimizing cognitive health.

Indexed as

Cognitive DysfunctionDepressionHIV InfectionsAdultFemaleHumansLongitudinal StudiesMiddle AgedNeuropsychological TestsUnited StatesCognitive impairmentCohort studyDepressive symptomsHIV

Identifiers

PMID41076158
PMCPMC12883071

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