Evidence map›Paper›PMID 41076120›Full record

ArticleJournal of advanced research2026

Rural-urban disparities in cardiovascular and other competing risk of death among cancer patients.

Tianwang Guan, Jiaqi He, Liangjia Zeng, Ruoyun Zhou, Kaiyi Chi, Yanhua Yang, Xueqi Xiao, Long Pan, Haowen Liang, Zhijuan Luo and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tianwang GuanGuangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, Cancer Center, The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; Cardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China.
Jiaqi HeThe 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China; Shenzhen School of Clinical Medicine, Southern Medical University, Guangdong 523059, China.
Liangjia ZengCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510180, China; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510000, China.
Ruoyun ZhouCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510180, China; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Kaiyi ChiCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Yanhua YangThe 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Xueqi XiaoCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; The Second Clinical Medical College, Southern Medical University, Guangzhou 510515, China.
Long PanCordeliers Research Center, Sorbonne Université, Inserm, Université Paris Cité, Paris, France.
Haowen LiangCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510180, China; Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou 510180, China.
Zhijuan LuoCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510180, China.
Renyu LiCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Mental Health, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510182, China.
Jiapeng WangCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Medical Imageology, The Second Clinical College of Guangzhou Medical University, Guangzhou 510180, China.
Xiaolin GaoCardio-Oncology Group, Medical Exploration and Translation Team, Guangzhou 510000, China; Department of Anesthesiology, The Second Clinical College of Guangzhou Medical University, Guangzhou 510180, China.
Rundong TaiGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Huiwan ChenGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Jujian YeGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Yushen KeGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Zhilin DengGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China.
Qingyi WeiResearch Institute for Cancer Control and Prevention, Great Bay Area Institute of Precision Medicine (Guangzhou), Guangzhou, China; Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China. Electronic address: weiqingyi@ipm-gba.org.cn.
Kang ZhangThe 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China; The Eye and Brain Center, State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: kang.zhang@gmail.com.
Caiwen OuGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou 510280, China; The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong 523059, China. Electronic address: oucaiwen@smu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRural-urban disparity of cancer is a major public health problem, with an unclear gap in noncancer death. It is important to evaluate rural-urban disparities in cardiovascular diseases (CVDs) and other competing death among cancer patients.

objectivesObserving urban-rural disparities and trends in noncancer deaths in the U.S. cancer population.

methodsTo address rural-urban disparities, we used proportions of deaths, age-adjusted mortality rates (AAMR), cumulative mortality rates, subdistribution hazard ratio (sHR), standardized mortality ratios (SMRs), absolute excess risks (AERs) and mediation analysis.

resultsBetween 1990 and 2017, there were 2,022,482 patients of 24 cancer sites, with a median follow-up of 11·8 years. Rural proportions of noncancer and CVD deaths in cancer patients were higher than urban ones. Rural AAMR of noncancer and CVD deaths surpassed urban one in cancer patients, who had higher cumulative mortality rates than urban counterparts in noncancer (sHR:1·21, 95 % confidence interval [CI]:1·19-1·22), CVDs (sHR:1·25, 95 % CI: 1·23-1·28), diabetes mellitus (sHR:1·24, 95 % CI:1·15-1·34), Alzheimer's disease (sHR:1·30, 95 % CI:1·21-1·39), pneumonia and influenza (sHR:1·30, 95 % CI:1·21-1·39) and chronic obstructive pulmonary disease and allied cond (sHR:1·32, 95 % CI:1·26-1·39). Compared with the general population, both rural (SMR:4·58, AER:218·03) and urban (SMR: 3·74, AER: 166·61) cancer patients had higher risks of noncancer death. Mediation analyses identified median household income and SEER stages as the mediators.

conclusionRural cancer patients had higher risks of noncancer death than urban counterparts, especially CVD-related deaths. Future targeted policy and public health interventions are needed to diminish the rural-urban gap in such death disparities.

Indexed as

Cardiovascular DiseasesHealth Status DisparitiesNeoplasmsRural PopulationUrban PopulationAgedFemaleHumansMaleMiddle AgedRisk FactorsUnited StatesCancerCardio-oncologyInequityMediation analysisNoncancer mortalityRural-urban disparity

Identifiers

PMID41076120
PMCPMC13316350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.