Evidence map›Paper›PMID 41076115›Full record

ArticleContemporary clinical trials2025

Nutrition Effects on Brain Outcomes and Recovery in Stroke after Hospitalization (NOURISH): Randomized controlled trial protocol and rationale.

Laurel Cherian, Puja Agarwal, Klodian Dhana, Vincent Carey, Mark A Espeland, Nancy Laranjo, Xavier Reilly, Cheng Hong, Pyone Maung, Chiquia Hollings and 15 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04337255 (MIND Diet and Dementia Prevention in Ischemic Stroke Patients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04337255 naactive not recruitingnot on this map

MIND Diet and Dementia Prevention in Ischemic Stroke Patients

TypeinterventionalSponsorRush University Medical CenterRan2021 to 2026Enrolled250ConditionsCognitive Decline, Dementia, Vascular, Alzheimer Disease, DementiaArmsBehavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Laurel CherianRush University Medical Center, Chicago, IL, USA. Electronic address: laurel_j_cherian@rush.edu.
Puja AgarwalRush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Chicago, IL, USA.
Klodian DhanaRush University Medical Center, Chicago, IL, USA.
Vincent CareyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mark A EspelandWake Forest University School of Medicine, Winston-Salem, NC, USA.
Nancy LaranjoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xavier ReillyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cheng HongThe University of Chicago, Chicago, IL, USA.
Pyone MaungRush University Medical Center, Chicago, IL, USA.
Chiquia HollingsRush University Medical Center, Chicago, IL, USA.
Beth LukaszewiczRush University Medical Center, Chicago, IL, USA.
Jennifer VentrelleRush University Medical Center, Chicago, IL, USA.
Jameszetta JamesRush University Medical Center, Chicago, IL, USA.
Amy TranRush University Medical Center, Chicago, IL, USA.
Santosh BasapurRush University Medical Center, Chicago, IL, USA.
Thomas HollandRush University Medical Center, Chicago, IL, USA.
Kristin R KruegerRush University Medical Center, Chicago, IL, USA.
Xiaoran LiuRush University Medical Center, Chicago, IL, USA.
Dixon YangRush University Medical Center, Chicago, IL, USA.
James R BrorsonThe University of Chicago, Chicago, IL, USA.
Rasha KhatibAurora Research Institute, Milwaukee, WI, USA.
Konstantinos ArfanakisRush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Chicago, IL, USA.
Lisa L BarnesRush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Chicago, IL, USA.
Christy TangneyRush University Medical Center, Chicago, IL, USA.
Neelum T AggarwalRush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Chicago, IL, USA.

Funding

MIND DIET AND DEMENTIA PREVENTION IN ISCHEMIC STROKE PATIENTSR01AG062637 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI AGGARWAL, NEELUM T. · 2020 to 2025
$16.3M
Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial designR61NS135583 · NINDS · UNIVERSITY OF CHICAGO · PI BRORSON, JAMES R. · 2024 to 2025
$762k
NIA NIH HHS L30 AG060512NIA NIH HHS R01 AG062637NINDS NIH HHS R61 NS135583
6 · The paper itself

Abstract

backgroundRisk of dementia doubles after stroke. There is limited information on reduction of risk, but diet is a significant modifiable risk factor for both vascular health and cognition.

objectiveNutrition effects on brain Outcomes and Recovery In Stroke after Hospitalization (NOURISH; registration no. NCT04337255) is a phase III randomized controlled trial designed to test the effects of the MIND diet on changes in cognition following an acute ischemic stroke. STUDY

methodsEligible participants aged 55 and older were randomized to either the MIND diet intervention facilitated by credentialled nutritionists plus post-stroke care (Coach) or a post-stroke care intervention led by health educators (Self) for 24-36 months. Repeated assessments included anthropometric measurements, cognitive testing, blood and urinary biomarkers, and a variety of validated post-stroke outcome measures and follow-up visits for up to 3 years, with MRI scans conducted on a subset of participants at baseline and the study's end. Unique features of this study include:

conclusionsThis study will evaluate the MIND diet intervention in preventing cognitive impairment in older adults after acute stroke. Findings will provide insights for the development of dietary guidelines for post-stroke care.

Indexed as

Cognitive DysfunctionIschemic StrokeStrokeStroke RehabilitationAgedClinical Trials, Phase III as TopicCognitionFemaleHospitalizationHumansMagnetic Resonance ImagingMaleMiddle AgedNutritional StatusRandomized Controlled Trials as TopicRecovery of FunctionAcute ischemic stroke survivorsCognitive declineDiet interventionMIND dietary patternPhase 3 randomized clinical trial

Identifiers

PMID41076115
PMCPMC12863194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.