Evidence map›Paper›PMID 41076065›Full record

ArticleChest2026

Impact of Positive Airway Pressure Therapy on Health Care Resource Use in Patients With OSA and Coronary Artery Disease.

Peter A Cistulli, Anita S Malik, Adam V Benjafield, Naomi Alpert, Caleb Woodford, Jean-Louis Pepin, Kimberly L Sterling, Kate V Cole, Atul Malhotra, Ann Cameron and 2 more

Abstract read
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peter A CistulliCharles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: Peter.cistulli@sydney.edu.au.
Anita S MalikResMed Science Center, San Diego, CA.
Adam V BenjafieldResMed Science Center, Sydney, NSW, Australia.
Naomi AlpertResMed Science Center, San Diego, CA.
Caleb WoodfordResMed Science Centre, Halifax, NS, Canada.
Jean-Louis PepinHP2 Laboratory, Institut National de la Sante et de la Recherche Medicale, Grenoble Alpes University, Grenoble, France.
Kimberly L SterlingResMed Science Center, San Diego, CA.
Kate V ColeResMed Science Center, San Diego, CA.
Atul MalhotraUniversity of California, San Diego, La Jolla, CA.
Ann CameronResMed Science Center, San Diego, CA.
Gemma FigtreeFaculty of Medicine and Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia; Cardiovascular Discovery Group, Kolling Institute of Medical Research, Sydney, NSW, Australia.
medXcloud Group

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundOSA is associated with coronary artery disease (CAD) risk. This study examined the impact of positive airway pressure (PAP) therapy adherence on health care resource use (HCRU) in patients with CAD and newly diagnosed OSA. RESEARCH QUESTION: Is adherence to PAP therapy associated with reduced HCRU in patients with CAD and OSA? STUDY DESIGN AND

methodsThis retrospective analysis linked administrative claims to objective PAP use data (ResMed AirView) for adults (≥ 18 years of age) with CAD who received a new diagnosis of OSA. Two-year adherence was defined by the number of 90-day time frames in which adherence criteria were met. Inverse probability of treatment weighting was applied to assess primary outcomes of emergency room (ER) visits and hospitalizations 1 and 2 years after the index date.

resultsThirty-two thousand nine hundred eleven patients were included (34.9% female; mean age, 60.9 years). Compared with adherent patients, nonadherent patients were slightly younger, more commonly female, and had higher prevalence of severe obesity and comorbidities. Compared with nonadherent patients, adherent patients made significantly fewer ER visits (-26% and -24%; P < .001) and all-cause hospitalizations (-35% and -39%; P < .001) in years 1 and 2, respectively. HCRU for intermediately adherent patients fell between that of adherent and nonadherent patients. After risk adjustment, the threshold for minimum nightly PAP use to derive a significant HCRU benefit was < 3 h/night for all outcomes and periods. A 4.7% to 5.9% reduction in HCRU rates with each additional hour per night of PAP use was noted.

interpretationIn real-world patients with CAD and newly diagnosed OSA, PAP therapy adherence was associated with lower HCRU. These findings strongly support the importance of diagnosing and treating OSA in these patients.

Indexed as

Continuous Positive Airway PressureCoronary Artery DiseaseHealth ResourcesPatient ComplianceSleep Apnea, ObstructiveAgedEmergency Room VisitsFemaleHospitalizationHumansMaleMiddle AgedRetrospective Studiesadherencecoronary artery diseasehealth care resource useOSApositive airway pressure

Identifiers

PMID41076065
PMCPMC13050181

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.