Evidence map›Paper›PMID 41076030›Full record

ArticleOphthalmology2026

Long-term Ocular Safety in Children Treated with Mitogen-Activated Protein Kinase Pathway Inhibitor Therapy.

Robert A Avery, Andrea M Gross, Chantal Cousineau-Krieger, Tiarnán D L Keenan, Taylor McManus, Connor J Dallas, Christopher Hampton, Andrea Baldwin, Fangming Jin, Kara Heisey and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Robert A AveryDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Andrea M GrossPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Chantal Cousineau-KriegerConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Tiarnán D L KeenanDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Taylor McManusConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Connor J DallasDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Christopher HamptonConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Andrea BaldwinClinical Research Directorate, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
Fangming JinDepartment of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kara HeiseyPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Kristen ZellerConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Grant T LiuDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Chinwe OkeaguConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Rachel J BishopConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Michael J FisherDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Brigitte C WidemannPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
M Teresa MagoneConsult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: teresa.magonedequadroscosta@nih.gov.

Funding

Therapies for patients with rare tumors and genetic tumor predispositionZIASC010354 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WIDEMANN, BRIGITTE · 2009 to 2025
$19.2M
Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA SC010354
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MEK inhibitor-associated retinopathyMitogen-activated protein kinase kinase pathway inhibitorsNeurofibromatosis 1Selumetinib

Identifiers

PMID41076030
PMCPMC12743595

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.