Evidence map›Paper›PMID 41076013›Full record

ArticleMucosal immunology2025

Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss.

Skye Y Tracey, Alexa C Blanchard, Sebastian A Wellford, William M Harbour, Alan R Tang, Dorian B McGavern, E Ashley Moseman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Skye Y TraceyDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA.
Alexa C BlanchardViral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Sebastian A WellfordDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
William M HarbourViral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Alan R TangViral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Dorian B McGavernViral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
E Ashley MosemanDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ashley.moseman@duke.edu.

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
Treatment of Primary Amoebic Meningoencephalitis via Modulation of Antibody Effector FunctionsR01NS121067 · NINDS · DUKE UNIVERSITY · PI MOSEMAN, E. ASHLEY · 2021 to 2025
$2.0M
Defining mucosal plasma cell origin, residence, and longevity in the upper airwayR01AI179729 · NIAID · DUKE UNIVERSITY · PI E. Ashley Moseman · 2025 to 2026
$1.3M
T cell/astrocyte fusions as a novel form of trained immunity to infectionR21NS133561 · NINDS · DUKE UNIVERSITY · PI MOSEMAN, E. ASHLEY · 2023 to 2024
$434k
Defining the molecular and anatomical basis of the blood-olfactory barrier (BOB)R21DC021260 · NIDCD · DUKE UNIVERSITY · PI MOSEMAN, E. ASHLEY · 2023 to 2023
$434k
NIAID NIH HHS R01 AI179729NIAID NIH HHS T32 AI052077NIDCD NIH HHS R21 DC021260NIGMS NIH HHS T32 GM145449NINDS NIH HHS R01 NS121067NINDS NIH HHS R21 NS133561
6 · The paper itself

Abstract

The upper airway is comprised of two distinct mucosal surface tissues, the respiratory mucosa (RM) and the olfactory mucosa (OM), both of which are constantly being exposed to airborne pathogens. The olfactory mucosa is responsible for detecting and conveying odorant information into the central nervous system, and infection poses serious neuroinvasion risk. Using vesicular stomatitis virus (VSV) as a model of olfactotropic viral infection,

Indexed as

Olfaction DisordersOlfactory MucosaRhabdoviridae InfectionsSmellVesiculovirusAnimalsDisease Models, AnimalHumansMetaplasiaMiceMice, Inbred C57BLNasal turbinatesNeurotropic infectionOlfactory immunityOlfactory mucosaRespiratory viral infection

Identifiers

PMID41076013
PMCPMC12724685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.