Evidence map›Paper›PMID 41075982›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2026

Geographic Measures of Early Life-Course Social Exposome in the Evaluation of Structural Neuroanatomy: A Scoping Review.

Eleanna M Melcher, Monica I Duran, Gabriella M Mamlouk, Leslie Christensen, Grace C George, Amy J H Kind

Abstract readScoping ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eleanna M MelcherDepartment of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, Wisconsin. Electronic address: emmelcher@wisc.edu.
Monica I DuranWaisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Gabriella M MamloukWisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Leslie ChristensenEbling Library for the Health Science, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Grace C GeorgeCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
Amy J H KindCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, Wisconsin; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Funding

The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
NIA NIH HHS R01 AG070883NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Life-course social exposome exposures may influence structural neuroanatomy in early life, thereby altering risk and protective factors implicated in the biological mechanisms of disease. The literature examining geospatially defined early-life social exposome exposures and their association with structural neuroanatomy has not been characterized. A systematic search was conducted in PubMed, Scopus (Elsevier), Web of Science Core Collection (Clarivate), PsycINFO (EBSCO), and Google Scholar. The study team dually screened 4960 records, 35 of which were included in the final review. Most articles identified an association between adverse social exposome exposures and aberrant structural neuroanatomy (n = 32). Studies assessed multiple developmental periods: infancy (n = 4), childhood (n = 27), early adolescence (n = 11), and late adolescence (n = 7). The Area Deprivation Index was the most widely used social exposome metric (n = 21). Future research should seek harmonized approaches to investigating the duration and magnitude of exposures and their association with brain structure and function.

Indexed as

Adverse Childhood ExperiencesBrainExposomeAdolescentChildHumansInfantNeuroanatomyEarly lifeExposomeGeospatial disadvantageLife-courseNeighborhood disadvantageNeuroimagingSocial exposomeStructural neuroanatomy

Identifiers

PMID41075982
PMCPMC12900494

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.