Evidence map›Paper›PMID 41075786›Full record

ArticleNeuron2025

Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling.

Amy J Gleichman, Riki Kawaguchi, Elle M Rathbun, Michael V Sofroniew, S Thomas Carmichael

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy J GleichmanDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA; Gene Therapy Institute, The Ohio State University, Columbus, OH, USA.
Riki KawaguchiCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Elle M RathbunDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Michael V SofroniewDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.
S Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: scarmichael@mednet.ucla.edu.

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael Gandal · 2020 to 2026
$9.6M
Mechanisms of White Matter Repair in Subcortical White Matter IschemiaR37NS102185 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2018 to 2024
$2.8M
Analysis and manipulation of astrocyte heterogeneity after strokeF32NS087783 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GLEICHMAN, AMY J. · 2014 to 2017
$172k
NICHD NIH HHS P50 HD103557NINDS NIH HHS F32 NS087783NINDS NIH HHS R37 NS102185
6 · The paper itself

Abstract

Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue repair are poorly understood, particularly across brain regions and stroke subtypes. We identified phenotypically and morphologically distinct zones of reactive astrocytes in mouse models of cortical and white matter stroke. Zone-specific transcriptomic analyses revealed that cortical, but not white matter, astrocytes upregulated transcriptional programs promoting the formation of new blood vessels, a key repair mechanism. Viral gain- and loss-of-function strategies showed that astrocytic Lamc1, in particular, is an endogenous mechanism by which cortical, but not white matter, astrocytes drive remodeling of larger-caliber brain microvessels. Exogenous induction of Lamc1 in white matter astrocytes improved vessel remodeling and repair and triggered differential T cell infiltration post stroke. Astrocyte subpopulations show region-specific responses to ischemia that can be leveraged to promote repair, including astrocyte-induced vascular remodeling.

Indexed as

AstrocytesCerebral CortexStrokeVascular RemodelingWhite MatterAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLangiogenesisastrocyteglial heterogeneityLamc1neural repairreactive astrocytestrokevascular remodelingwhite matter stroke

Identifiers

PMID41075786
PMCPMC12614840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.