Evidence map›Paper›PMID 41075513›Full record

ArticleStem cell research2025

Generation of an induced pluripotent stem cell line from a patient with Varicose veins.

Chikage Noishiki, Amit Manhas, Shaunak S Adkar, Dipti Tripathi, David Wu, Safa Sadat, Lu Liu, Karim Sallam, Nicholas J Leeper, Eri Fukaya and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chikage NoishikiStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA.
Amit ManhasStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA.
Shaunak S AdkarDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA; Baszucki Family Vascular Surgery Biobank, USA.
Dipti TripathiDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA; Baszucki Family Vascular Surgery Biobank, USA.
David WuStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA.
Safa SadatBaszucki Family Vascular Surgery Biobank, USA.
Lu LiuStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA.
Karim SallamStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA.
Nicholas J LeeperStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA.
Eri FukayaDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA.
Nazish SayedStanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA; Baszucki Family Vascular Surgery Biobank, USA. Electronic address: sayedns@stanford.edu.

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA CardiomyopathyR01HL158641 · NHLBI · STANFORD UNIVERSITY · PI SAYED, NAZISH · 2021 to 2025
$2.2M
Unraveling the role of endothelium in chemotherapy-induced cardiotoxicityR01HL161002 · NHLBI · STANFORD UNIVERSITY · PI SAYED, NAZISH · 2022 to 2025
$1.6M
Stem Cell Model of Varicose VeinsF32HL170716 · NHLBI · STANFORD UNIVERSITY · PI NOISHIKI, CHIKAGE · 2024 to 2024
$86k
NHLBI NIH HHS F32 HL170716NHLBI NIH HHS R01 HL158641NHLBI NIH HHS R01 HL161002NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Chronic venous disease is among the most common vascular diseases globally. Varicose veins (VV), characterized by permanent dilation, elongation, and tortuosity of superficial veins, is a manifestation of chronic venous disease. Here, we generated an induced pluripotent stem cell (iPSC) line from PBMCs obtained from a patient with VV. The iPSC line exhibited typical morphology, maintained undifferentiated hPSC state markers, demonstrated a normal karyotype, and successfully differentiated into all three germ layers. This iPSC line provides a valuable platform to model VV pathogenesis and investigate the molecular mechanisms underlying venous dysfunction.

Indexed as

Induced Pluripotent Stem CellsVaricose VeinsCell DifferentiationCell LineHumansMaleInduced Pluripotent Stem CellsInflammationVaricose Veins

Identifiers

PMID41075513
PMCPMC12757079

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.