Evidence map›Paper›PMID 41075409›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2025

Myeloid ADAM17 induces ST2

Joseph C Lownik, Matthew P Zellner, Jared Farrar, Anuj Tharakan, Francesco S Celi, Daniel H Conrad, Rebecca K Martin

Abstract read
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph C LownikDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States; Center for Clinical and Translational Research, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Matthew P ZellnerDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Jared FarrarCenter for Clinical and Translational Research, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Anuj TharakanDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Francesco S CeliDivision of Endocrinology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Daniel H ConradDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Rebecca K MartinDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States. Electronic address: Rebecca.Martin@vcuhealth.org.

Funding

STRUCTURE/FUNCTION OF THE LYMPHOCYTE FCE RECEPTORR01AI018697 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, REBECCA KELLEY · 1985 to 2018
$6.5M
Metabolic perturbations in conventional dendritic cells modulate Tfh13 induction in asthmatic sensitizationR01HL162991 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Rebecca Kelley Martin · 2023 to 2026
$2.3M
IL-25 as a master regulator of extrafollicular benign IgER56AI139658 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, REBECCA KELLEY · 2019 to 2019
$380k
NHLBI NIH HHS R01 HL162991NIAID NIH HHS R01 AI018697NIAID NIH HHS R56 AI139658
6 · The paper itself

Abstract

Obesity is a detrimental disease that affects almost all physiological functions of the person that is afflicted. Secreted TNF alpha (sTNF) levels are directly correlated in obesity with weight gain and morbidity, as well as metabolic dysregulation.

Indexed as

ADAM17 ProteinInflammationInterleukin-1 Receptor-Like 1 ProteinMyeloid CellsObesityT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaAdipose TissueAnimalsDiet, High-FatMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutADAM17 ProteinAdam17 protein, mouseIl1rl1 protein, mouseInterleukin-1 Receptor-Like 1 ProteinTumor Necrosis Factor-alphaADAM17Adipose tissue myeloid cellsObesity-induced inflammationTACETNF alphaT regulatory cells

Identifiers

PMID41075409
PMCPMC13327260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.