Evidence map›Paper›PMID 41075346›Full record

ArticleJournal of neuroimmunology2025

The hidden toll: Atrophy of key central nervous system relays in African American women with multiple sclerosis.

Nabeela Nathoo, Nur Neyal, Jiye Son, Christopher G Schwarz, Elizabeth J Atkinson, Holly A Morrison, June Kendall Thomas, John D Port, Kejal Kantarci, Orhun H Kantarci and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nabeela NathooDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Medicine (Neurology), University of Alberta, Edmonton, AB, Canada.
Nur NeyalCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Jiye SonDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Elizabeth J AtkinsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Holly A MorrisonCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
June Kendall ThomasDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
John D PortDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA; Women's Health Research Center, Mayo Clinic, Rochester, MN, USA.
Orhun H KantarciDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Burcu ZeydanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA; Women's Health Research Center, Mayo Clinic, Rochester, MN, USA. Electronic address: Zeydan.burcu@mayo.edu.

Funding

Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
NIAMS NIH HHS K12 AR084222
6 · The paper itself

Abstract

backgroundAfrican American persons with MS (AApwMS) have more aggressive clinical and imaging outcomes than White American pwMS (WApwMS), including lower brain and spinal cord (SC) volumes. However, imaging studies are lacking considering the effects of sex, race, and ethnicity together.

objectiveCompare MS clinical and imaging features among AApwMS and WApwMS, incorporating the modifying effects of sex, race, and ethnicity.

methodsClinical variables and MRI were obtained for AApwMS and WApwMS.

resultsThirty-five MRIs in 28 AApwMS (61 % female) and 255 MRIs in 91 WApwMS (68 % female) were evaluated. AApwMS had a shorter MS disease duration (median 5.9 years, IQR 2.7-13.1) compared to WApwMS (9.4 years, IQR 3.8-17.0; p = 0.034). Fewer AApwMS ever used disease modifying therapy (69 %) compared to WApwMS (92 %; p < 0.001), while the likelihood of having progressive MS and developing severe disability were similar between groups (p > 0.05). AA women with MS had smaller thalamus (p = 0.016), cerebellar grey matter (p = 0.025), and SC-C2 (p = 0.005) volumes than WA women with MS. Although multiple brain and SC regions were smaller in AA men than WA men with MS, the differences were not significant.

conclusionInteraction between sex, race, and ethnicity may influence differences in imaging metrics of key central nervous system relays, likely preceding clinical worsening in MS.

Indexed as

Black or African AmericanBrainMultiple SclerosisSpinal CordAdultAtrophyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWhiteAfrican AmericanAtrophyCerebellumEthnicityMagnetic resonance imagingMultiple sclerosisRaceSexSpinal cordThalamus

Identifiers

PMID41075346
PMCPMC12705190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.