Evidence map›Paper›PMID 41075343›Full record

ReviewCurrent opinion in neurobiology2025

From bladder to brain: How you know when it's time to go.

Anne M J Verstegen, Kara L Marshall

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anne M J VerstegenDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Kara L MarshallDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address: kara.marshall@bcm.edu.

Funding

Bladder fullness signaling and the neural control of continenceR01DK125708 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VERSTEGEN, ANNE ("HANNEKE") · 2020 to 2024
$1.9M
Mapping Mechanosensory Circuits from the Bladder to Barrington's NucleusR01DK142807 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Anne (Hanneke) Verstegen · 2025 to 2026
$1.6M
Molecular mechanisms of mechanosensing in the urinary tractR00DK128621 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MARSHALL, KARA L · 2022 to 2024
$737k
NIDDK NIH HHS R00 DK128621NIDDK NIH HHS R01 DK125708NIDDK NIH HHS R01 DK142807
6 · The paper itself

Abstract

The decision to urinate relies on assessing bladder fullness and context to determine an appropriate time and place to go. Any disruption in this interoceptive process results in frequent and sometimes debilitating consequences in daily life. Recent work has uncovered key pathways and brain regions that contribute to the sense of bladder stretch and the control of urinary reflexes, but many open questions remain. Here, we review the known mechanisms that convey sensory information from the bladder to the brain and back down again, and we highlight the knowledge gaps and opportunities for better understanding this system, which will be critical to develop effective therapies for urinary dysfunction.

Indexed as

BrainUrinary BladderUrinationAnimalsHumans

Identifiers

PMID41075343
PMCPMC13102143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.