ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Plasma p-tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Seven tesla MRI reveals amygdala and hippocampal subfield atrophy in dementia with Lewy bodies.Alzheimer's research & therapy · 2026Article
- Plasma pTau217 as a Prognostic, Monitoring, and Risk-Stratification Biomarker of Clinical Progression in Lewy Body Disease.medRxiv : the preprint server for health sciences · 2026Article
- Plasma p-tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThis study evaluated whether plasma phosphorylated tau-217 (p-tau217), amyloid beta (Aβ)42/40, and their combination could serve as biomarkers of Aβ co-pathology across the Lewy body continuum, where Aβ is frequently observed from prodromal to symptomatic stages.
methodsIndividuals with dementia with Lewy bodies (DLB), Parkinson's disease (PD), and their shared prodromal stage, isolated rapid eye movement (REM) sleep behavior disorder (iRBD) underwent plasma sampling, Aβ-PET, and cognitive testing.
resultsHigher plasma p-tau217, lower Aβ42/40, and their interaction were associated with greater Aβ-PET uptake. Individuals with higher-than-median p-tau217 and lower-than-median Aβ42/40 showed the highest Aβ burden. Both biomarkers predicted Aβ-PET positivity, but only p-tau217 correlated with cognition. Among 44 iRBD participants followed prospectively, elevated baseline p-tau217 predicted phenoconversion to overt Lewy body disease. DISCUSSION: Plasma p-tau217 and Aβ42/40 may serve as accessible biomarkers of cerebral Aβ pathology and help identify individuals across the Lewy body continuum who could benefit from Aβ-targeted therapy. HIGHLIGHTS: Plasma phosphorylated tau-217 (p-tau217) and amyloid beta (Aβ)42/40 predict cerebral Aβ burden in the Lewy body continuum. Both biomarkers individually show high accuracy for identifying Aβ positron emission tomography positivity. Plasma p-tau217, but not Aβ42/40, is associated with cognitive performance. Elevated plasma p-tau217 predicts future phenoconversion in isolated rapid eye movement sleep behavior disorder.
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