Evidence map›Paper›PMID 41075130›Full record

ArticleAging clinical and experimental research2025

Abnormal maximal tubular reabsorption of phosphate as a novel biomarker of physical dysfunction in older adults.

Mengzhen Sun, Shixuan Zhang, Hui Zhang, Na Zhang, Weicheng Wu, Yuanfei Cao, Mengjing Wang, Jing Chen, Xiaoyan Jiang, Xuehui Sun and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengzhen Sun *Human Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Shixuan Zhang *Research and Innovation Center, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Hui ZhangHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Na ZhangHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Weicheng WuHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Yuanfei CaoHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Mengjing WangNephrology, Huashan Hospital, Fudan University, Shanghai, China.
Jing ChenNephrology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoyan JiangState Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Xuehui SunHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Xiaofeng WangHuman Phenome Institute and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China. xiaofengwang71@163.com.
Qi ZhangDepartment of Cardiology, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, China. zqroom@163.com.

Funding

China natural science grant 81730017Key research and development plan of the Ministry of Science and Technology 2020YFC2005003National Natural Science Foundation of China-Youth Science Fund 82301768Research Foundation of Huashan Hospital Fudan university Shanghai China 2021QD057Shanghai Municipal Health Commission 202340287Shanghai Municipal Science and Technology Major Project 2023SHZDZX02Shenkang three-year action plan project SHDC2020CR4014
6 · The paper itself

Abstract

backgroundPhysical dysfunction is a preclinical stage of disability in older adults, linked to severe adverse outcomes such as death and hospitalization. Maximal tubular reabsorption of phosphate (TmP/GFR), as a key biomarker of phosphate metabolism, may be related to physical dysfunction, but this relationship has not yet been explored.

methodsUsing data from the Rugao Longitudinal Ageing Study (RLAS), longitudinal logistic regression was employed to explore the relationship between abnormal TmP/GFR and physical dysfunction. For validation, the UK Biobank dataset was combined, and mendelian randomization (MR) was conducted to investigate causality. The maximal phosphate reabsorption was assessed using TmP/GFR, while physical dysfunction were evaluated through grip strength and the Timed Up and Go (TUG) test.

resultsDuring the four-year follow-up, 89 (13.55%) and 279 (40.85%) participants were identified as having a new onset of decreased grip and TUG. The abnormal TmP/GFR population had a significantly higher risk of decreased grip (OR 2.03, 95% CI 1.20-3.49) and decreased TUG (OR 1.49, 95% CI 1.05-2.12). MR analysis demonstrated the causal effect of TmP/GFR dysfunction population had significantly lower grip and lower walking speed.

conclusionThis study first identifies abnormal TmP/GFR as a novel biomarker of physical dysfunction in older adults. Additionally, its causal relationship further substantiates the reliability of this finding. Abnormal TmP/GFR enables early detection of physical dysfunction, facilitating the prevention of severe adverse outcomes.

Indexed as

AgingKidney TubulesPhosphatesAgedAged, 80 and overBiomarkersFemaleGlomerular Filtration RateHand StrengthHumansLongitudinal StudiesMaleMiddle AgedBiomarkersPhosphatesCausal relationshipMaximal tubular reabsorption of phosphateOlder adultsPhysical dysfunction

Identifiers

PMID41075130
PMCPMC12515114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.