ReviewEndocrine2025
Evaluating prolactin levels during bilateral inferior petrosal sinus sampling: a potential solution to false-negative results in Cushing's disease diagnosis.
Review in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
backgroundThis review aims to evaluate the utility of prolactin (PRL) measurements during bilateral inferior petrosal sinus sampling (BIPSS) as a diagnostic tool for Cushing’s disease (CD), focusing on its potential to enhance diagnostic accuracy and reduce false-negative results.
methodsThe review synthesizes existing literature on the role of PRL in confirming correct catheter placement during BIPSS, examining various studies that assess its effectiveness as an indicator of pituitary venous effluent. It discusses the mechanisms behind PRL adjustments, the impact of different stimulation methods, and the interpretation of PRL-normalized adrenocorticotropic hormone (ACTH), ratios.
resultsProlactin measurements have shown promise in identifying unsuccessful catheterization and improving diagnostic accuracy in patients with suspected CD. Studies indicate that a baseline PRL IPS: P ratio of ≥ 1.8 suggests successful catheter placement, while normalized ACTH/PRL ratios can differentiate between CD and ectopic ACTH secretion. However, the interpretation of intermediate values remains unclear, necessitating further investigation.
conclusionsIncorporating PRL measurements into BIPSS protocols may enhance the diagnostic process for CD by reducing false negatives and improving patient management. Despite its potential benefits, further prospective studies are needed to establish standardized cut-off values and clarify the clinical implications of PRL measurements in this context.
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