Evidence map›Paper›PMID 41075110›Full record

ArticleGeroScience2026

GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments.

Hongying Wang, Chia-Shan Wu, Danilo Landrock, Ariel Nevarez, Shanrun Liu, Anna Thalacker-Mercer, Yanfeng Zhang, Jamie I Baum, Sunja Kim, Bingzhong Xue and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongying WangDepartment of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
Chia-Shan WuDepartment of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
Danilo LandrockDepartment of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
Ariel NevarezDepartment of Nutrition, Texas A&M University, College Station, TX, 77843, USA.
Shanrun LiuFlow Cytometry and Single Cell Core Facility, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Anna Thalacker-MercerDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Yanfeng ZhangGenetics Research Division, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jamie I BaumCenter for Human Nutrition, Department of Food Science, University of Arkansas System Division of Agriculture, Fayetteville, AR, 72701, USA.
Sunja KimTexas A&M Preclinical Phenotyping Core, Texas A&M Institute for Genome Sciences and Society, Texas A&M University, College Station, TX, 77843, USA.
Bingzhong XueDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Yuxiang SunDepartment of Nutrition, Texas A&M University, College Station, TX, 77843, USA. yuxiang.sun@tamu.edu.

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Sakhila Banu · 2019 to 2026
$13.0M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
Crosstalk between sensory ghrelin signaling and adipose tissue sympathetic outflow regulates metabolic homeostasisR01DK125081 · NIDDK · GEORGIA STATE UNIVERSITY · PI XUE, BINGZHONG · 2020 to 2023
$2.3M
Nutrient-sensing GHS-R in macrophage reprogramming and inflamm-agingR01AG064869 · NIA · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2023
$2.1M
The role of GHS-R in macrophage reprogramming during meta-inflammationR01DK118334 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2022
$1.2M
Ghrelin deficiency predisposes mice to aging-associated inflammation through compromised gut function and microbiota dysbiosisR21AG061726 · NIA · TEXAS A&M AGRILIFE RESEARCH · PI WU, CHIA-SHAN · 2019 to 2020
$429k
Nathan Shock Center, University of Alabama at Birmingham P30AG050886National Institute of Food and Agriculture NIFA 1022378National Institute of Food and Agriculture USDA Hatch 7001445NIA NIH HHS NIH AG064869NIA NIH HHS NIH R21AG061726NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG064869NIA NIH HHS R21 AG061726NIDDK NIH HHS NIH R01DK118334NIDDK NIH HHS R01 DK118334NIDDK NIH HHS R01 DK125081NIEHS NIH HHS P30 ES029067NIEHS NIH HHS P30ES029067
6 · The paper itself

Abstract

Aging is accompanied by progressive declines in metabolic and cognitive functions. Growth hormone secretagogue receptor (GHSR), a receptor for the gut hormone ghrelin, is highly expressed in neurons and plays a crucial role in metabolic regulation. We previously reported that aged global GHSR-ablated mice are lean and insulin-sensitive, and that neuronal GHSR-deleted mice (Syn1-cre;Ghsr

Indexed as

AgingCognitive DysfunctionNeuronsReceptors, GhrelinAnimalsEnergy MetabolismInsulin ResistanceMaleMiceGhsr protein, MouseReceptors, GhrelinAgingCognitionGHSRInflammationMetabolismObesityThermogenesis

Identifiers

PMID41075110
PMCPMC13575014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.