Evidence map›Paper›PMID 41075050›Full record

ArticleAging clinical and experimental research2025

Polypharmacy appropriateness in Italian Long-Term Care Facilities: the nationwide prescription day point survey.

Alba Malara, Alberto Zucchelli, Caterina Trevisan, Gilda Borselli, Raffaele Antonelli Incalzi, Graziano Onder, Antonio Cherubini, Alessandra Marengoni, Alessandro Morandi, Anna Castaldo and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alba MalaraSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Alberto ZucchelliSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Caterina TrevisanSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Gilda BorselliSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Raffaele Antonelli IncalziSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Graziano OnderSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Antonio CherubiniSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Alessandra MarengoniSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Alessandro MorandiSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Anna CastaldoSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Dario LeoscoSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Giuseppe Dario TestaSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy.
Andrea UngarSocietà Italiana di Gerontologia e Geriatria, Via G.C. Vanini, 5, 50129, Florence, Italy. andrea.ungar@unifi.it.ORCID https://orcid.org/0000-0002-8965-4523
Prescription Day LTCFs Workgroup

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global population aging is increasing the demand for Long-Term Care Facilities to support older adults with complex health needs. The Prescription Day LTCFs project is a national multicenter point-prevalence study, conducted by the Italian Society of Gerontology and Geriatrics in collaboration with the ANASTE Humanitas Foundation, investigated medication prescription patterns and administration practices in 3,400 residents across 82 facilities in Italy. Participants had a mean age of 84.7 years, with a high prevalence of frailty (49.7%) and polypharmacy (84.8% taking five or more medications). Common chronic conditions included hypertension, dementia, and dysphagia. The study highlighted the complexity of pharmacological regimens, emphasizing risks related to potentially inappropriate medications, drug-drug interactions, and frequent modifications of solid oral dosage forms to facilitate administration in residents with swallowing difficulties or cognitive impairment. These complexities contribute to increased nursing workload. Despite advances in deprescribing research, polypharmacy remains highly prevalent, underlining the need for tailored prescribing guidelines. Variability among Long Term Care Facilities reflects differences in organization and regional healthcare frameworks. The findings provide a valuable foundation for developing strategies to optimize medication management, enhance safety, and improve quality of care in Italian Long Term Care Facilities. This study also offers insights to inform healthcare policies and best practices in pharmacological care for older adults in Long Term Care settings. PRE BIO CE n. 0027032 (20/06/2024), National Ethics Committee, Istituto Superiore di Sanità, Rome, Italy.

Indexed as

Long-Term CareNursing HomesPolypharmacyAgedAged, 80 and overFemaleHumansInappropriate PrescribingItalyMaleSurveys and QuestionnairesLong-Term Care FacilitiesMedication administrationMedication prescriptionPolypharmacy

Identifiers

PMID41075050
PMCPMC12515235

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.