ArticleMolecular biology reports2025
Sodium perborate tetrahydrate targets pancreatic cancer cells by inducing apoptosis, arresting the cell cycle, and disrupting cytoskeletal integrity.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatic cancer remains one of the most lethal malignancies worldwide due to its aggressive nature and resistance to conventional therapies. Novel agents that can simultaneously inhibit proliferation, induce apoptosis, and suppress metastasis are urgently needed. In this study, we investigated the anti-cancer potential of the boron-containing compound SPT in pancreatic cancer cell lines.
methodsThe PSN-1 and BXPC-3 cell lines were treated with SPT at concentrations that corresponded to the half-maximal inhibitory concentration (IC
resultSPT treatment induced a marked increase in apoptosis in both cell lines, which is demonstrated by the significant increase in both early and late apoptotic populations. The results of the study revealed that flow cytometry had revealed G0/G1 phase arrest in PSN-1 cells and G2/M arrest in BXPC-3 cells, which was associated with differential expression of CDKs, ATM, and ATR. Furthermore, SPT significantly inhibited DNA synthesis and colony formation. In addition, a number of genes associated with migration, including RhoA, Rac1, Cdc42, Vinculin and Tensin2, were found to be downregulated.
conclusionSodium perborate tetrahydrate (SPT) emerges as a promising therapeutic compound, exhibiting selective cytotoxicity against pancreatic cancer cells by disrupting proliferation, cell cycle progression, and migratory potential.
Indexed as
Identifiers
41075045What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.