Evidence map›Paper›PMID 41075039›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Periodic limb movements during sleep and progression of sleep apnea: a longitudinal analysis from the Wisconsin sleep cohort.

Maria P Mogavero, Giuseppe Lanza, Oliviero Bruni, Amedeo Antoci, Ugo Faraguna, Luigi Ferini-Strambi, Raffaele Ferri

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria P MogaveroVita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0001-6662-2281
Giuseppe LanzaClinical Neurophysiology Research Unit and Sleep Research Centre, Oasi Research Institute-IRCCS, Troina, Italy.ORCID 0000-0002-5659-662X
Oliviero BruniDepartment of Human Neuroscience, Sapienza University, Rome, Italy.ORCID 0000-0003-2207-1398
Amedeo AntociClinical Neurophysiology Research Unit and Sleep Research Centre, Oasi Research Institute-IRCCS, Troina, Italy.ORCID 0009-0001-4555-1063
Ugo FaragunaDepartment of Developmental Neuroscience, IRCCS Stella Maris Foundation, Calambrone, Pisa, Italy.ORCID 0000-0002-4814-7218
Luigi Ferini-StrambiVita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0003-2867-5424
Raffaele FerriClinical Neurophysiology Research Unit and Sleep Research Centre, Oasi Research Institute-IRCCS, Troina, Italy. rferri@oasi.en.it.ORCID 0000-0001-6937-3065

Funding

INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
EPIDEMIOLOGY OF SLEEP-DISORDERED BREATHING IN ADULTSR01HL062252 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PEPPARD, PAUL E · 1999 to 2013
$14.1M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
Longitudinal Associations of Midlife Sleep Duration and Quality with Later Life Cognitive and Physical Functioning DeclineR01AG058680 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HAGEN, ERIKA W · 2018 to 2021
$2.6M
The REST Study: A Longitudinal, Bidirectional Examination of Retirement And SleepR01AG036838 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI PEPPARD, PAUL E · 2010 to 2014
$2.5M
Ministero della Salute Ricerca Corrente" (RC n. 2787055)NCRR NIH HHS UL1 RR025011NHLBI NIH HHS 75N92019R002NHLBI NIH HHS R01 HL062252NHLBI NIH HHS R24 HL114473NIA NIH HHS R01 AG036838NIA NIH HHS R01 AG058680
6 · The paper itself

Abstract

purposeTo explore whether Periodic Limb Movements during Sleep (PLMS) are an intrinsic feature of sleep physiology or influenced by the progression of sleep apnea using longitudinal data.

methodsThis study analyzed data from 39 participants in the Wisconsin Sleep Cohort who transitioned from no or mild (Apnea-Hypopnea Index - AHI < 10) to moderate-to-severe sleep apnea (AHI > 15). Polysomnographic recordings measured PLMS and related leg movement indices, including respiratory-related limb movements (RRLM), at baseline and follow-up.

resultsAHI increased significantly between baseline and follow-up, while the PLMS index remained stable. Predictors of follow-up PLMS index were limited to baseline PLMS index, with no significant effects from AHI or other confounding factors. Increased indices of short-interval and isolated leg movements were observed but did not impact the PLMS index.

conclusionPLMS appear to be a relatively consistent feature of individual sleep patterns, independent of respiratory disturbances. This novel approach, examining pre-apnea recordings, provides unique insights into the interplay of limb movements and respiratory events in sleep-disordered breathing.

Indexed as

Nocturnal Myoclonus SyndromeSleep Apnea, ObstructiveAdultCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPolysomnographyWisconsinPeriodic limb movements in sleep (PLMS)PolysomnographyRespiratory-related limb movements (RRLM)Sleep apnea progressionWisconsin sleep cohort

Identifiers

PMID41075039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.