ArticleJournal of computer-aided molecular design2025
Investigation of the role of microtubule on the activity of the mitotic kinesin EG5 using multiscale modelling: unravelling molecular mechanisms.
Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Molecular Dynamics Simulations Provide Further Insights into the Allosteric Regulation of the Kinesin-5 Motor Domain by Loop 5.Journal of chemical information and modeling · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules are crucial components of the mitotic spindle, essential in chromosome segregation during cell division. EG5, a kinesin motor protein, has emerged as a critical player in this process by promoting the separation of sister chromatids. Dysregulation of EG5 function is associated with tumorigenesis, making it a promising target for cancer therapeutics. Hence, understanding EG5's molecular mechanisms is a key to developing better therapies with fewer side effects. Here, we investigate the mechanisms by which EG5 interacts with microtubules and how this interaction enhances its motor activity. Utilizing computational methods, we probe the role of microtubule binding in the allosteric regulation of EG5 dynamics. Our results demonstrate that microtubule binding significantly enhances EG5's dynamic flexibility and motor activity, while inhibitors targeting distinct allosteric sites disrupt this interaction. These insights provide a molecular framework for the rational design of EG5-targeted inhibitors, with potential implications for anticancer drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.