ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Global hotspots and trends in AMPA receptor research (2000-2025): a bibliometric and visualization analysis.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study.Gene therapy · 2026Article
- The role of ionotropic glutamate receptors in Alzheimer's disease: A scientometric analysis.Journal of Alzheimer's disease : JAD · 2026Article
- Artificial intelligence in glioma research: a bibliometric analysis of global trends, hotspots, and future directions.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AMPA receptors (AMPARs) are critical excitatory ionotropic glutamate receptors involved in synaptic transmission, plasticity, and various neurological disorders. From 2000 to present (up to 2025), extensive research has explored their roles in brain function and disease, yet a comprehensive bibliometric analysis of this field is lacking. This study aims to provide a systematic bibliometric overview of AMPAR research from 2000 to present, identifying key trends, influential contributors, and emerging hotspots to guide future investigations. Data were retrieved from Web of Science, PubMed, and Scopus, encompassing 37,000 distinct publications. Bibliometric tools (CiteSpace, VOSviewer, and Bibliometrix) were employed to analyze publication trends, country/institution contributions, journal metrics, author productivity, and keyword clusters. The United States led in publication output (6,142 articles) and citations (410,626), followed by China and Japan. The Journal of Neuroscience and Neuron were the top journals, while Huganir RL was the most cited author. Research hotspots evolved from fundamental AMPAR properties (e.g., subunit composition) to disease associations (e.g., Alzheimer's, depression) and therapeutic strategies (e.g., AMPAR modulators). Keyword analysis revealed four themes: biochemical properties, physiological functions, pathological roles, and therapeutic targets. AMPAR research has transitioned from basic neurophysiology to translational applications, with growing emphasis on neurological and psychiatric disorders. Future directions include elucidating native AMPAR complexes, trafficking dynamics, and precision therapeutics. This study highlights the field's progression and underscores the need for interdisciplinary collaboration to address unresolved challenges.
Indexed as
Identifiers
41074965What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.