Evidence map›Paper›PMID 41074827›Full record

ArticleNMR in biomedicine2025

Optimal Variable Flip Angle Schemes for Hyperpolarized MR Kinetic Modeling Robust to RF Field Variations.

Marie Frederikke Garnæs, Rie Beck Olin, Pernille R Jensen, Jan Henrik Ardenkjaer-Larsen, Kristoffer Hougaard Madsen, Lars G Hanson

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marie Frederikke GarnæsDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0009-0008-2750-2517
Rie Beck OlinDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0003-1718-8196
Pernille R JensenDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0003-4359-848X
Jan Henrik Ardenkjaer-LarsenDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0001-6167-6926
Kristoffer Hougaard MadsenDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0001-8606-7641
Lars G HansonDepartment of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0002-8204-6912

Funding

Danish National Research Foundation DNRF124ERC Synergy 856432Novo Nordisk Foundation NNF19OC0055825
6 · The paper itself

Abstract

Hyperpolarized carbon-13 magnetic resonance has enabled the real-time observation of biochemical pathways in living cellular systems. Pharmacokinetic modeling of such experiments provides estimates of conversion rates between metabolites, which, in turn, can be used to distinguish between healthy and diseased tissues, for example. This work focuses on choosing time-varying flip angle schemes that minimize the uncertainty of model parameter estimates by maximizing the Fisher information while taking into account B

Indexed as

Magnetic Resonance ImagingModels, BiologicalRadio WavesComputer SimulationHumansKineticsMagnetic Resonance SpectroscopyMonte Carlo Methodhyperpolarized carbon‐13 magnetic resonanceoptimal experiment designpharmacokinetic modeling

Identifiers

PMID41074827
PMCPMC12514949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.