SynthesisThe European journal of neuroscience2025
A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.
Synthesis in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- The effects of transcranial random noise stimulation on excitation/inhibition balance in ADHD.NeuroImage. Clinical · 2026Trial
- Beyond neural oscillations: Stress-related aperiodic activity and aperiodic-oscillatory spectral covariation.iScience · 2026Article
- Task-Related Aperiodic EEG (1/f) Activity in Autism.Autism research : official journal of the International Society for Autism Research · 2026Article
- Potential mechanisms and functional significance of aperiodic neural activity.Nature human behaviour · 2026Review
- Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026Article
- Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis.eLife · 2026Article
- Periodic and aperiodic contributions to EEG delta power are translatable and complementary Angelman syndrome biomarkers.Communications medicine · 2026Article
- Resting-state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course.Developmental cognitive neuroscience · 2026Article
- sBOSC: A Method for Source-Level Identification of Neural Oscillations in Electromagnetic Brain Signals.Psychophysiology · 2026Article
- Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer's diseases with cognitive decline.GeroScience · 2026Article
- Diminished variability of alpha and beta band-limited power as a neural signature in schizophrenia.Translational psychiatry · 2026Article
- Normative modeling of MEG brain oscillations across the human lifespan.Communications biology · 2026Article
- Scale-Free Neurodynamics as Functional Fingerprint of Brain Regions.Bioengineering (Basel, Switzerland) · 2026Article
- Increased Aperiodic Exponents Track Depression Symptom Severity.bioRxiv : the preprint server for biology · 2026Article
- Critical Dynamics in the Association Cortex Predict Higher Intelligence in Typically Developing Children.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Early aperiodic EEG changes in preclinical and prodromal Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- A structured narrative review on VNS-treated drug-resistant epilepsy: EEG markers, neurochemical mechanisms, and future biomarker-driven computational directions.Frontiers in neuroscience · 2026Review
- Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction.Therapeutic advances in psychopharmacology · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aperiodic neural activity-activity with no characteristic frequency-has increasingly become a common feature of study, including in clinical work. Reports investigating aperiodic activity from patients from a broad range of clinical disorders have sought to evaluate aperiodic activity as a putative biomarker relating to diagnosis or treatment response and/or as a potential marker of underlying physiological activity. However, there is thus far no clear consensus on if and how aperiodic neural activity relates to clinical disorders. This systematic literature review, following PRISMA guidelines, examines reports of aperiodic activity in electrophysiological recordings from human patients with psychiatric and/or neurological disorders, finding 177 reports across 38 disorders. Results are summarized to evaluate current findings and examine what can be learned as pertains to the analysis, interpretations and overall utility of aperiodic neural activity in clinical investigations. Aperiodic activity is commonly reported to relate to clinical diagnoses, with 32 of 38 disorders reporting a significant effect in diagnostic and/or treatment-related studies. However, there is variation in the consistency of results across disorders, with the heterogeneity of patient groups, disease aetiologies and treatment status arising as common themes. Overall, the current variability of results, potentially confounding covariates, and limitations in current understanding of aperiodic activity suggest further work is needed before aperiodic activity can be established as a potential biomarker and/or marker of underlying pathological physiology. A series of recommendations are proposed to assist with guiding productive future work on the clinical utility of studying aperiodic neural activity.
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