Evidence map›Paper›PMID 41074631›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Pregnant Women With Ulcerative Colitis Have a Higher Risk of Delivering Small-For-Gestational-Age Infants: The Japan Environment and Children's Study (JECS).

Tamami Tsuzuki, Marina Minami, Ryuhei Nagai, Yusuke Oki, Hedeyuki Miyachi, Masamitsu Eitoku, Narufumi Suganuma, Nagamasa Maeda, Japan Environment and Children's Study Group

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In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tamami TsuzukiDepartment of Obstetrics and Gynecology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID https://orcid.org/0000-0002-3071-1829
Marina MinamiIntegrated Center for Advanced Medical Technologies (ICAM-Tech), Kochi Medical School Hospital, Nankoku, Kochi, Japan.
Ryuhei NagaiDepartment of Obstetrics and Gynecology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Yusuke OkiDepartment of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Hedeyuki MiyachiDepartment of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Masamitsu EitokuDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Narufumi SuganumaDepartment of Environmental Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Nagamasa MaedaDepartment of Obstetrics and Gynecology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Japan Environment and Children's Study Group

Funding

Ministry of Environment
6 · The paper itself

Abstract

aimUlcerative colitis primarily affects individuals of reproductive age, raising concerns regarding its impact on pregnancy, lactation, and postpartum outcomes. Although numerous international studies exist, research on the Japanese population remains limited. This study aimed to analyze data from a large-scale nationwide cohort in Japan.

methodsData were derived from a prospective birth cohort study conducted between 2011 and 2014 that recruited pregnant women in early pregnancy across Japan. Of the 97 075 pregnancies, 214 were complicated by ulcerative colitis. These were compared with 96 861 pregnancies without a history of ulcerative colitis in terms of background characteristics, perinatal outcomes, and neonatal findings.

resultsPregnant women with ulcerative colitis were older and had a lower smoking rate than those without the condition. Gestational weight gain was lower in the ulcerative colitis group than in the control group. The proportion of small-for-gestational-age infants was higher in pregnancies complicated by ulcerative colitis. This risk is further elevated in patients with anemia or inflammation during early pregnancy.

conclusionsThere is limited research on the impact of ulcerative colitis on pregnancy in Japan. This study found that pregnancies complicated by ulcerative colitis were associated with a higher risk of delivering small-for-gestational-age infants. Further studies with more detailed data on disease status are needed to assess disease activity and perinatal risk better.

Indexed as

Colitis, UlcerativeInfant, Small for Gestational AgePregnancy ComplicationsPregnancy OutcomeAdultFemaleHumansInfant, NewbornJapanPregnancyProspective Studiesinflammatory bowel diseaseJECS studypregnancysmall‐for‐gestational‐ageulcerative colitis

Identifiers

PMID41074631
PMCPMC12514660

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.