Evidence map›Paper›PMID 41074618›Full record

ArticleJournal of surgical oncology2025

Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study.

Cristina Taliento, Gennaro Scutiero, Giuseppe Cucinella, Vito Chiantera, Giovanni Pontrelli, Marko Klaric, Dragan Belci, Martin Steinkasserer, Stefano Restaino, Ruby Martinello and 14 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Cristina TalientoDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.ORCID https://orcid.org/0000-0003-0278-1202
Gennaro ScutieroDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Giuseppe CucinellaGynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS, Napoli, Italy.
Vito ChianteraGynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS, Napoli, Italy.
Giovanni PontrelliDepartment of Gynecology and Obstetrics, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsius Medical University (PMU), Bolzano-Bozen, Italy.
Marko KlaricClinical Hospital Center Rijeka, Clinic for Gynecology and Obstetrics, Rijeka, Croatia.
Dragan BelciDepartment of Gynaecology, General Hospital Pula, Pula, Croatia.
Martin SteinkassererDepartment of Gynecology and Obstetrics, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsius Medical University (PMU), Bolzano-Bozen, Italy.
Stefano RestainoDepartment of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Ruby MartinelloDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Orsola BrasileDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Martina ArcieriDepartment of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Sara PregnolatoDepartment of Medicine (DMED), University of Udine, Udine, Italy.
Giulia PellecchiaDepartment of Medicine (DMED), University of Udine, Udine, Italy.
Giulia SoraciDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Rosa TaratufoloDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Carmelia MilanoDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.
Marcello DesgroObstetrics and Gynaecology Clinic, Policlinico Hospital of Abano Terme, Padua, Italy.
Francesca DaviàObstetrics and Gynaecology Clinic, Policlinico Hospital of Abano Terme, Padua, Italy.
Mariano Catello Di DonnaGynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS, Napoli, Italy.
Dino BecicDepartment of Gynaecology, General Hospital Pula, Pula, Croatia.
Sara NotaroDepartment of Gynecology and Obstetrics, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsius Medical University (PMU), Bolzano-Bozen, Italy.
Giuseppe VizzielliDepartment of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Pantaleo GrecoDepartment of Medical Sciences, Obstetrics and Gynecology Unit, Ferrara, Italy.

Funding

T.C. is supported by the Department of Medical Sciences, University of Ferrara, through a grant awarded under the '5×1000 Young Researchers 2025' funding program.
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThis study aims to evaluate the predictive factors associated with failed sentinel lymph node (SLN) mapping in a large, retrospective cohort of patients with early-stage endometrial cancer (EC).

methodsWe retrospectively evaluated a series of EC patients who underwent laparoscopic SLN mapping with intracervical indocyanine green (ICG) injection in five referred oncological centers from January 2019 to March 2024. We compared the clinical and pathological features of bilateral and failed SLN mapping, which was defined as either unilateral mapping or no SLN mapping. Logistic regression was used to identify predictors of failure.

resultsAmong 623 analyzed patients, 437 (70.14%) had a successful bilateral procedure. On univariate analysis, age (p = 0.03), non-endometrioid histology (p = 0.02) and previous vaginal delivery (p = 0.015) were significant associated with failed SLN mapping. On multivariable analysis, only increasing age (OR 1.03; 95% CI, 1.01-1.04, p = 0.03) and non-endometrioid histology (OR 1.81; 95% CI, 1.01-3.19) were independently associated with unsuccessful procedure. No significant differences were observed for BMI, enlarged lymph nodes, intraoperative lysis of adhesion, LVSI, grade 3, and FIGO stage.

conclusionsIncreasing age and non-endometrioid histology are independent predictors of bilateral SLN mapping failure in EC patients undergoing SLN mapping with cervical ICG injection.

Indexed as

Endometrial NeoplasmsSentinel Lymph NodeSentinel Lymph Node BiopsyAdultAgedFemaleFollow-Up StudiesHumansIndocyanine GreenLymphatic MetastasisMiddle AgedRetrospective StudiesIndocyanine Greenendometrial cancerfailed SLN mappingICG injectionpredictive factorssentinel lymph node

Identifiers

PMID41074618
PMCPMC12661265

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.