ArticleEpilepsia2026
Nanoparticle-encapsulated neuropeptide Y provides robust seizure protection in SCN1A-derived epilepsy.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier.International journal of nanomedicine · 2026Review
- Nanoparticle-encapsulated neuropeptide Y provides robust seizure protection in SCN1A-derived epilepsy.Epilepsia · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
objectiveNeuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that is expressed primarily by γ-aminobutyric acidergic (GABAergic) interneurons. NPY has widespread effects on the brain, at both the cellular (e.g., reducing excitatory glutamatergic transmission) and circuit levels (e.g., increasing food intake, improving learning and memory, increasing seizure resistance). Previous studies have demonstrated antiseizure effects of NPY following invasive brain delivery methods or gene therapy approaches to increase the expression of NPY or its receptor activity. However, these routes of administration pose challenges for translation into clinical practice.
methodsTo overcome these obstacles, we generated a nanoparticle formulation to encapsulate neuropeptides. In the current study, we evaluated the ability of nanoparticle-encapsulated NPY (NP-NPY) to increase resistance to 6 Hz-, pentylenetetrazole-, and hyperthermia-induced seizures in mouse models of SCN1A-derived epilepsy. We also examined the ability of NP-NPY treatment to protect against spontaneous seizures in Scn1a
resultsWe found that intranasal NP-NPY administration was able to provide robust protection against induced seizures in two mouse models of SCN1A-derived epilepsy and reduce spontaneous seizure frequency in Scn1a SIGNIFICANCE: These results provide support for further evaluation of NP-NPY as a treatment for SCN1A-derived epilepsy and possibly other epilepsy subtypes.
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Registered trials
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