SynthesisActa paediatrica (Oslo, Norway : 1992)2026
Infant Formula for the Prevention and Treatment of Neonatal Hypoglycaemia: A Systematic Review and Meta-Analysis.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oral glucose solution for the treatment of persistent asymptomatic neonatal hypoglycemia: a randomized, double-blind, placebo-controlled trial.European journal of pediatrics · 2026Trial
- Translational Initiative to Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
aimNeonatal hypoglycaemia is a common metabolic disorder in newborns; if severe or prolonged, it can lead to brain injury. Formula is sometimes used to treat neonatal hypoglycaemia. This study aims to synthesise evidence on the effectiveness of infant formula for the prevention and treatment of neonatal hypoglycaemia.
methodsRandomised controlled trials (RCTs) and cohort studies comparing infants given formula to those who were not were included. Four databases and four trial registries were searched. Study quality was evaluated using the Cochrane Risk of Bias-1 tool for RCTs and the Newcastle-Ottawa Scale for cohort studies.
resultsWe screened titles and abstracts of 6711 records and full texts of 56 records. We included 12 studies: one RCT and 11 cohort studies. For prevention, the evidence is very uncertain about the effect of formula on neonatal hypoglycaemia (621 infants, OR 3.01 [0.53 to 17.13], p = 0.21, I
conclusionsThe effect of formula in preventing neonatal hypoglycaemia remains uncertain; although formula may be more effective than oral dextrose gel in correcting hypoglycaemia.
trial registrationThis review was registered in PROSPERO (CRD42024581348).
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Registered trials
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