Evidence map›Paper›PMID 41074552›Full record

ArticleAging cell2025

Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging.

Erin Baker, Encarnacion Montecino-Rodriguez, Shili Xu, Sotirios Tetradis, Adrien Rouault, Oscar I Estrada, Kenneth Dorshkind

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erin BakerDepartments of Pathology and Laboratory Medicine, UCLA School of Dentistry, Los Angeles, California, USA.
Encarnacion Montecino-RodriguezDepartments of Pathology and Laboratory Medicine, UCLA School of Dentistry, Los Angeles, California, USA.
Shili XuMolecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, UCLA School of Dentistry, Los Angeles, California, USA.
Sotirios TetradisDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, California, USA.
Adrien RouaultDepartments of Pathology and Laboratory Medicine, UCLA School of Dentistry, Los Angeles, California, USA.
Oscar I EstradaDepartments of Pathology and Laboratory Medicine, UCLA School of Dentistry, Los Angeles, California, USA.
Kenneth DorshkindDepartments of Pathology and Laboratory Medicine, UCLA School of Dentistry, Los Angeles, California, USA.ORCID 0000-0002-9005-631X

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Immunobiology of B Cell DifferentiationR37AI021256 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DORSHKIND, KENNETH ALLAN · 2009 to 2018
$3.8M
IMMUNOBIOLOGY OF B CELL DIFFERENTIATIONR01AI021256 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DORSHKIND, KENNETH ALLAN · 1985 to 2007
$2.3M
NCI NIH HHS P30 CA016042NIAID NIH HHS R01 AI021256NIAID NIH HHS R37 AI021256NIH HHS AI021256
6 · The paper itself

Abstract

B cell development declines with age, but how structural changes in the marrow environment contribute to that process is incompletely understood. Multiplexed volumetric imaging revealed that B lineage cells were enriched near bone, and trabecular bone in particular, in young mice. However, B cell progenitors were depleted from these regions in strains of old mice that exhibited senile osteoporosis. In striking contrast, the age-related decline of B lymphopoiesis was attenuated in mice in which bone mass was maintained over the lifespan and could be completely abrogated by concomitantly blocking TLR4 signaling. In addition to demonstrating that developing B lineage cells are not randomly distributed in the marrow, these results indicate that the age-related decline in B lymphopoiesis is influenced by the loss of salutary and not just an increase in inhibitory signals.

Indexed as

AgingB-LymphocytesCell LineageOsteoporosisToll-Like Receptor 4AnimalsLymphopoiesisMiceMice, Inbred C57BLSignal TransductionTlr4 protein, mouseToll-Like Receptor 4agingB cellsbone marrowenvironment

Identifiers

PMID41074552
PMCPMC12686596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.