ArticlePhysiological reports2025
Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER.Physiological reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain-specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory exchange ratio (RER), and body composition in C57BL/6 and BALB/cJ mice. Male and female mice underwent 4 weeks of voluntary wheel running, followed by sub-maximal and maximal treadmill tests in a metabolic chamber. Results indicate differences in running volume across sexes and strains did not consistently predict changes in physiological adaptations. Female C57BL/6 mice, which ran three times more than males on average, exhibited higher submaximal VO2 compared to their male counterparts and to female BALB/cJ mice, despite no differences in RER. In contrast, male BALB/cJ mice, which ran nearly double the distance of their female counterparts, showed a modest decrease in average RER. During maximal treadmill tests, male BALB/cJ mice demonstrated enhanced endurance capacity, characterized by increased distance run and a trend towards lower RER and blood lactate levels at exhaustion, despite no significant changes in VO2 max. Regarding body composition, female C57BL/6 mice experienced a reduction in fat mass and an increase in lean mass, whereas no significant changes were observed in BALB/cJ mice of either sex. The study highlights the need to consider sex- and strain-specific factors when evaluating metabolic and endurance adaptations, and suggests VO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.