Evidence map›Paper›PMID 41074203›Full record

ArticleBiology of sex differences2025

Sex-related differences in phenotype and nigro-striatal degeneration of c-rel

Edoardo Parrella, Vanessa Porrini, Michele Mario Gennari, Marina Benarese, Federico Del Gallo, Anna Andrioli, Chiara Fritzsch, Marina Bentivoglio, Paolo Francesco Fabene, Marina Pizzi

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In one paragraph

Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. The influence of trait anxiety on performance in the CatWalk test.Frontiers in behavioral neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Edoardo ParrellaDepartmental Faculty of Medicine, Saint Camillus International University of Health Sciences, Rome, Italy.
Vanessa PorriniDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Michele Mario GennariDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Marina BenareseDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Federico Del GalloSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, Verona, Italy.
Anna AndrioliSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, Verona, Italy.
Chiara FritzschDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Marina BentivoglioSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, Verona, Italy.
Paolo Francesco FabeneSection of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Marina PizziDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. marina.pizzi@unibs.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex is an important factor in the development and symptom expression of Parkinson's disease (PD). Risk of developing PD, motor and non-motor symptoms and response to treatment differ between men and women, with women showing lower disease incidence, later onset of motor deficits and generally milder symptoms than men. We previously reported that male mice lacking the NF-κB/c-Rel protein (c-rel

methodsNigro-striatal alterations as well as motor and non-motor symptoms were assessed in aged c-rel

resultsLikewise c-rel

conclusionsOur results show that, differently from aged males, c-rel

Indexed as

Corpus StriatumParkinson DiseaseProto-Oncogene Proteins c-relSex CharacteristicsSubstantia NigraAnimalsDisease Models, AnimalDopaminergic NeuronsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeProto-Oncogene Proteins c-relDATMotor symptomsNF-κB/c-RelNigrostriatal degenerationNon-motor symptomsParkinson’s diseaseSexual dimorphism

Identifiers

PMID41074203
PMCPMC12512402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.