Evidence map›Paper›PMID 41074196›Full record

ReviewAnimal microbiome2025

Intestinal microbiota dynamics in piglets: the interplay with swine enteric coronavirus infections and implications for disease control.

Yang Liu, Bo Dong, Yong-Le Yang, Ya-Qing Zhang, Yanan Zhang, Dan Pan, En-Zhong Du, Shu Jeffery Zhu, Bin Wang, Yao-Wei Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animal microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang Liu *State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Bo Dong *Agro-Biological Gene Research Center of Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Guangzhou, China.
Yong-Le Yang *Xianghu Laboratory, Hangzhou, China.
Ya-Qing ZhangDepartment of Veterinary Medicine, Zhejiang University, Hangzhou, China.
Yanan ZhangDepartment of Veterinary Medicine, Zhejiang University, Hangzhou, China.
Dan PanState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
En-Zhong DuYEBIO Bioengineering Co., Ltd. of Qingdao, Qingdao, China.
Shu Jeffery ZhuDepartment of Veterinary Medicine, Zhejiang University, Hangzhou, China. shuzhu@zju.edu.cn.
Bin WangState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China. wangbin1990@scau.edu.cn.
Yao-Wei HuangState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China. yhuang@scau.edu.cn.

Funding

National Natural Science Foundation of China 32302873National Natural Science Foundation of China U22A20521
6 · The paper itself

Abstract

Infections of swine enteric coronavirus (SECoV), including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), cause severe diarrhea in piglets and result in substantial losses to the pig industry. The intestinal microbiota plays a crucial role in SECoV disease progression and outcomes, yet current research largely focuses on specific age groups or intestinal segments. This review provides a comprehensive analysis of the dynamic microbiota changes in piglets after SECoV infections across different ages and intestinal regions. It discusses differential microbiota analyses, functional changes, metabolic products, alongside their effects on immune responses. Additionally, we explore fecal bacterial transplantation as a potential intervention and highlight the role of the microbiota in either promoting or inhibiting SECoV infections. The development of advanced research tools, including culturomics, sequencing technologies, and multi-omics approaches, is pivotal in understanding the intricate relationship between the porcine intestinal microbiota and SECoV infections, offering potential strategies for preventing and controlling SECoV-related diseases.

Indexed as

Fecal bacterial transplantationGut culturomicsGut microbiotaImmune responsesProbioticsSwine enteric coronavirus

Identifiers

PMID41074196
PMCPMC12513024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.