ArticleOrphanet journal of rare diseases2025
Performance of the Egoo test for phenylalanine measurement in females with phenylketonuria.
Article in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAccurate measurement of phenylalanine (Phe) is a requirement for the diagnosis and management of individuals with Phenylketonuria (PKU). The current methods for quantifying Phe, plasma amino acids, and dried blood spots (DBS) have several analytical limitations and are not suitable for self-monitoring. This study evaluated the validity of a point-of-care testing (POCT) device, the Egoo Phe Test, in a sample of females with PKU who participated in a five-day camp intervention.
methodsBlood samples were collected from 20 participants (median age: 18 years; IQR: 16, 28.3) on the first (day 1) and/or final (day 5) day of camp for Phe quantification by plasma amino acids, DBS, and the Egoo Phe Test. Phe concentrations determined by these three methods were compared to assess agreement.
resultsOn both days of camp, strong positive agreement based on Lin's concordance correlation coefficient (p
conclusionsThe Egoo Phe Test demonstrated potential as a substitute for DBS, but additional research in larger and more diverse clinical cohorts is required. Future research should focus on improving accuracy and defining analytical targets that consider the clinical impact of Phe test performance on management of patients with PKU. CLINICAL TRIAL NUMBER: not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.