ArticleNutrition journal2025
The relationship between vitamin D levels and depression: a genetically informed study.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Vitamin D and Postpartum Depression: A Narrative Review.Clinics and practice · 2026Review
- Development and validation of a prediction model for psychological distress in patients with differentiated thyroid cancer undergoing ¹³¹I therapy.Frontiers in endocrinology · 2026Article
- Bibliometric and Visualized Analysis of the Global Research Status and Trends of the Association Between Vitamin D and Osteoarthritis in the Last Two Decades.Journal of multidisciplinary healthcare · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundLow vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.
methodsWe investigated the genetic overlap and causal relationships between depression (N = 589,356) and vitD levels (N = 417,580) using genome-wide association study (GWAS) summary statistics. We performed genome-wide and local genetic correlation analyses, followed by quantification of polygenic overlap variants. Shared genetic loci were identified and mapped to genes, which were further analyzed through gene expression and lifespan brain expression trajectory analyses. Bidirectional causal relationships were examined using multiple Mendelian randomization approaches.
resultsWe observed significant negative genetic correlations (r
conclusionsOur findings elucidate the shared biological mechanisms underlying the relationship between vitD and depression, suggesting that vitD play an important role in the development of depression through altered early neurodevelopmental processes.
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Registered trials
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